Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTA1 (P68135) - Overview - Molecular Target Synopsis

Protein


ACTA1, Actin, alpha skeletal muscle
UniProt P68135

Also Known as ACTS_RABIT, ACTA1, ACTA

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

6GVC
STRUCTURE OF ARHGAP12 BOUND TO G-ACTIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ACTA1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: ACTA1 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTA1 is active in the following subcellular-locations: actin filament, actin filament bundle, cell body, cytoplasm, filamentous actin, filopodium, lamellipodium, skeletal muscle myofibril, stress fiber, striated muscle thin filament.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTA1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ACTA1 there are:
151 structures (595 chains) solved
131 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ACTA1 is solved in complex with the approved drug(s):

211/TROLAMINE (2HMP_A, 2HMP_B),
SUC/SUCROSE (1QZ6_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTA1 has been screened with compounds ( bioactivities). (see details)