Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTA1 (P68133) - Overview - Molecular Target Synopsis

Protein


ACTA1, Actin, alpha skeletal muscle
UniProt P68133

Also Known as ACTS_HUMAN, ACTA1, ACTA

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity). Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACTA1 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTA1 is active in the following subcellular-locations: actin cytoskeleton, actin filament, blood microparticle, cell body, cytosol, extracellular exosome, extracellular space, filopodium, lamellipodium, sarcomere, stress fiber, striated muscle thin filament.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTA1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EFM-192B, NCI-H2596, C3A

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, H1-hESC, SK-N-SH

(see details)

3D Structures


For ACTA1 there are:
63 structures (245 chains) solved
60 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTA1 has been screened with compounds ( bioactivities). (see details)