Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTC1 (P68032) - Overview - Molecular Target Synopsis

Protein


ACTC1, Actin, alpha cardiac muscle 1
UniProt P68032

Also Known as ACTC_HUMAN, ACTC1, ACTC

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
377ENSG00000159251ENST00000290378ENSP00000290378P68033-1, P68035-1, Q3ZC07-1, P68034-1, Q6P640-1, P68032-1

Sub-cellular localization


UniProt: ACTC1 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTC1 is active in the following subcellular-locations: actin filament, actomyosin, blood microparticle, cell body, cytoplasm, cytosol, extracellular exosome, extracellular space, filopodium, focal adhesion, glutamatergic synapse, I band, lamellipodium, membrane, sarcomere.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTC1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SF_539, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SJCRH30, NCI-H2172, NCI-H196

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to ACTC1 there are:
64 structures (246 chains) solved
61 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTC1 has been screened with compounds ( bioactivities). (see details)