Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TNNC1 (P63316) - Overview - Molecular Target Synopsis

Protein


TNNC1, Troponin C, slow skeletal and cardiac muscles
UniProt P63316

Also Known as TNNC1_HUMAN, TNNC1, TNNC

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

6MV3
NMR STRUCTURE OF THE CNTNC-CTNI CHIMERA BOUND TO CALCIUM DESENSITIZER W7
RCSB/PDB
Inspect Structure
See all 3D Structures for TNNC1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
161ENSG00000114854ENST00000232975ENSP00000232975P63316-1, P02591-1
105ENSG00000114854ENST00000496590ENSP00000420596

Drugs


TNNC1 is targeted by Approved Drug Bepridil. (see details)
Bepridil

Sub-cellular localization


GO terms: TNNC1 is active in the following subcellular-locations: cardiac Troponin complex, cytosol, troponin complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TNNC1 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_4, HCT_15, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVCAR-4, CAL51, NCI-H2596

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, HeLa-S3, SK-N-SH

(see details)

3D Structures


For TNNC1 there are:
38 structures (49 chains) solved
15 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

TNNC1 is solved in complex with the approved drug(s):

TFP/TRIFLUOPERAZINE (1WRK_A, 1WRK_B, 1WRL_A, 1WRL_B, 1WRL_C, 1WRL_D, 1WRL_E, 1WRL_F),
DXC/DEOXYCHOLIC ACID (3RV5_A, 3RV5_B, 3RV5_C, 3RV5_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TNNC1 has been screened with compounds ( bioactivities). (see details)