Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTG2 (P63267) - Overview - Molecular Target Synopsis

Protein


ACTG2, Actin, gamma-enteric smooth muscle
UniProt P63267

Also Known as ACTH_HUMAN, ACTG2, ACTA3, ACTL3, ACTSG

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACTG2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTG2 is active in the following subcellular-locations: blood microparticle, cell body, cell periphery, cytoplasm, cytosol, extracellular exosome, extracellular space, filopodium, lamellipodium, myosin filament.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTG2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, SNB_75, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 578T, Hs 255.T, Hs 675.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, AG445, NHLF

(see details)

3D Structures


At greater than 90% identity similarity to ACTG2 there are:
67 structures (246 chains) solved
64 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTG2 has been screened with compounds ( bioactivities). (see details)