Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTG1 (P63261) - Overview - Molecular Target Synopsis

Protein


ACTG1, Actin, cytoplasmic 2
UniProt P63261

Also Known as ACTG_HUMAN, ACTG1, ACTG

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TWF1, CAPZB, cofilin and profilin (PubMed:28493397).

6G2T
HUMAN CARDIAC MYOSIN BINDING PROTEIN C C1 IG-DOMAIN BOUND TO NATIVE CARDIAC THIN FILAMENT
RCSB/PDB
Inspect Structure
See all 3D Structures for ACTG1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTG1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, TK_10, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-436, RMUG-S, SNU-475

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, NHLF, SK-N-SH

(see details)

3D Structures


For ACTG1 there are:
4 structures (21 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTG1 has been screened with compounds ( bioactivities). (see details)