Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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gadC (P63235) - Overview - Molecular Target Synopsis

Protein


gadC, Probable glutamate/gamma-aminobutyrate antiporter
UniProt P63235

Also Known as GADC_ECOLI, gadC, acsA, xasA

Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.

4DJI
STRUCTURE OF GLUTAMATE-GABA ANTIPORTER GADC
RCSB/PDB
Inspect Structure
See all 3D Structures for gadC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: gadC is active in the following subcellular-locations: cell inner membrane.
GO terms: gadC is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project gadC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For gadC there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis