Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SUMO1 (P63165) - Overview - Molecular Target Synopsis

Protein


SUMO1, Small ubiquitin-related modifier 1
UniProt P63165

Also Known as SUMO1_HUMAN, SUMO1, SMT3C, SMT3H3, UBL1

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376). Covalently attached to KCNB1; UBE2I increases cross-linking with KCNB1 and PIAS1 decreases cross-links with KCNB1 (PubMed:19223394). Interacts with SAE2, RANBP2, PIAS1 and PIAS2. Interacts with PRKN. Covalently attached to a number of proteins such as IKFZ1, PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52. Interacts with USP25 (via ts SIM domain); the interaction weakly sumoylates USP25. Interacts with SIMC1, CASP8AP2, RNF111 AND SOBP (via SIM domains). Interacts with BHLHE40/DEC1. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1.

6J4I
A CONSERVED AND BURIED EDGE-TO-FACE AROMATIC INTERACTION IN SUMO IS VITAL FOR THE SUMO PATHWAY
RCSB/PDB
Inspect Structure
See all 3D Structures for SUMO1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SUMO1 is active in the following subcellular-locations: cell membrane, cytoplasm, nucleus, nucleus membrane, nucleus speckle, pml body.
GO terms: SUMO1 is active in the following subcellular-locations: cytosol, dendrite, fibrillar center, heterochromatin, nuclear body, nuclear envelope, nuclear membrane, nuclear pore, nuclear speck, nuclear stress granule, nucleolus, nucleoplasm, nucleus, plasma membrane, PML body, SUMO activating enzyme complex, synapse, XY body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SUMO1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SN12C, NCI_H522, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-157, BT-20, NCI-H1373

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For SUMO1 there are:
34 structures (58 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis