Molecular Target Synopsis
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RAN (P62826) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed126
Chains with at least one site assessed as druggable using the strict criteria14
Chains with at least one site assessed as druggable using the relaxed criteria115


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3GJX_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 73.8 38.6 Yes No
2 empty 2.53 59.5 22.8 No No
3 empty 2.08 63.1 17.2 No No
4 empty 1.98 59.7 18.2 No No
5 empty 2.4 67.4 20.7 No No
6 empty 2.23 54.4 12.5 No No
7 empty 2.11 78.2 9.6 No No
8 empty 2.32 61.1 10.2 No No
9 empty 2.17 54.5 10.2 No No
10 empty 2.42 60.3 12 No No
4HB0_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 64.8 51.2 Yes No
2 empty 2.51 61.9 22.1 No No
3 empty 1.78 62.6 17.1 No No
4 empty 1.65 45.3 14.5 No No
5 empty 1.66 52.8 17.3 No No
6 empty 2.12 55.7 14.4 No No
7 empty 2.24 58.6 12.9 No No
8 empty 2.34 64.5 19.6 No No
9 empty 2.47 59.4 11.1 No No
10 empty 1.72 70.8 8 No No
3CH5_A GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 66.6 23.7 No No
2 empty 2.37 65.5 19.7 No No
3 bound 2.02 70.8 17.7 No No
4 empty 2.55 65.7 18.3 No No
5 empty 2.12 61.7 20.3 No No
6 empty 2.25 67.1 21.3 No No
7 empty 2.01 68.3 14.3 No No
8 empty 2.23 57.1 11.4 No No
9 empty 2.24 62.7 13.9 No No
10 empty 1.82 58.4 11.9 No No
3GJ4_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.58 68.6 32.1 Yes No
2 empty 2.25 67.4 17 No No
3 empty 2.45 61.2 20.5 No No
4 bound 2.22 71.7 13.7 No No
5 empty 1.99 65.8 11.4 No No
6 empty 2.32 64.2 11.8 No No
7 empty 2.04 69.1 16.2 No No
8 empty 2.08 77.3 11.7 No No
9 empty 2.25 66.9 13.4 No No
10 empty 2.49 64.4 15.7 No No
1A2K_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 70.3 26.1 Yes No
2 empty 2.31 65 22.2 No No
3 empty 2.04 67.3 16.7 No No
4 bound 2.1 76.6 14.6 No No
5 empty 1.94 69.3 15.1 No No
6 empty 1.86 65.4 15.2 No No
7 empty 2.23 57.1 14 No No
8 empty 2.07 69.7 12.4 No No
9 empty 1.94 54.6 14.8 No No
10 empty 2.15 69.3 19.4 No No
5CLL_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 71.6 32.1 Yes No
2 empty 1.98 64.4 26 No No
3 empty 2.26 56.2 20.4 No No
4 empty 2.49 61.6 25.7 No No
5 empty 2.11 60.2 13.3 No No
6 empty 1.02 59.8 11.5 No No
7 empty 1.9 54.9 9.5 No No
8 empty 2.65 60.4 10.3 No No
9 empty 2.35 59.9 8 No No
10 empty 1.76 47.8 8.6 No No
5CIQ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 65.1 32.8 Yes No
2 empty 2.14 65.1 31.6 No No
3 empty 2.49 66 29 No No
4 empty 2.22 62.2 18.3 No No
5 bound 2.02 71.1 15.6 No No
6 empty 2.05 60.2 14.7 No No
7 empty 2.44 62.8 9.5 No No
8 empty 2.08 74.6 9.9 No No
9 empty 2.01 66.4 11 No No
10 empty 1.87 56.7 8.9 No No
1I2M_A GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 70.1 18.2 No No
2 empty 2.25 63.8 24 No No
3 empty 2.31 65.5 25.5 No No
4 empty 2.3 64.3 20.8 No No
5 empty 2.08 63.8 14.8 No No
6 empty 1.91 60.3 16 No No
7 empty 1.98 64 16 No No
8 empty 2.36 57.8 13.5 No No
9 bound 2.24 66.4 10.6 No No
10 empty 2.44 68.9 9.4 No No
1K5G_G GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.14 51.9 25.9 Yes No
2 bound 2.11 73.9 29.8 No No
3 empty 2.6 60.6 25.7 No No
4 empty 1.5 63.4 17.1 No No
5 empty 1.81 58.6 12.8 No No
6 empty 2.15 57.4 13.4 No No
7 empty 1.37 56.6 11.1 No No
8 empty 2.11 65 13.5 No No
9 empty 2.18 60.8 11.5 No No
10 empty 2.13 53.4 13.7 No No
3GJ0_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 62.9 26.2 Yes No
2 empty 2.29 64.7 28.9 No No
3 empty 2.31 63.9 15 No No
4 empty 2.15 60.8 22.3 No No
5 bound 2.02 72.5 14.2 No No
6 empty 1.96 71.1 15.6 No No
7 empty 2.31 59.5 18.4 No No
8 empty 2.2 64.7 11.7 No No
9 empty 2.58 58.6 11.6 No No
10 empty 1.96 60.8 14.2 No No
1A2K_E GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 60.9 33 Yes No
2 empty 2.12 74.7 17.6 No No
3 empty 2.3 61.8 19.8 No No
4 bound 2.04 65.2 17 No No
5 empty 1.83 64.6 13.9 No No
6 empty 1.9 67 14.6 No No
7 empty 2.47 71.5 13.1 No No
8 bound 1.66 71.9 10.4 No No
9 bound 2.04 67.8 9.9 No No
10 empty 2.15 67.4 10.5 No No
5CJ2_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 62.3 27.6 Yes No
2 empty 2.43 66.7 26.5 No No
3 empty 2.25 58.7 27.8 No No
4 bound 2.08 70.7 19 No No
5 empty 2.07 62.6 17.3 No No
6 empty 2.19 65.7 16.6 No No
7 empty 2.24 62.1 16.4 No No
8 empty 1.85 65.9 10 No No
9 empty 2.04 64.9 9.4 No No
10 empty 1.81 64.5 10.5 No No
5ZPU_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 52.9 29.9 Yes No
2 bound 2.13 76.2 34.3 No No
3 empty 2.57 59 25.2 No No
4 empty 1.89 58.2 22.4 No No
5 empty 1.98 59.5 14.2 No No
6 empty 2.04 57.2 15.9 No No
7 empty 1.77 58.3 11.2 No No
8 empty 2.32 70.6 10.4 No No
9 empty 2.03 62.3 10 No No
10 empty 2.48 58.3 10.8 No No
1WA5_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 73 31.8 Yes No
2 empty 2.64 62.4 37.9 No No
3 empty 2.13 64.2 13.9 No No
4 empty 2.52 66.2 17.5 No No
5 empty 2.33 57.3 13.2 No No
6 empty 2.2 59.6 8.9 No No
7 empty 2.61 56.7 7 No No
8 empty 2.93 52.9 11.7 No No
9 empty 1.95 61.4 9.1 No No
10 empty 2.31 60.4 9.7 No No
5CIW_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 63.6 32.1 Yes No
2 empty 2.44 63.4 18.6 No No
3 empty 2.5 70.5 19 No No
4 bound 2.05 69.9 14.3 No No
5 empty 2.26 62.7 16.2 No No
6 empty 2.23 64 23.5 No No
7 empty 2.18 62.7 14.5 No No
8 empty 2.19 56 11.6 No No
9 empty 2.24 69.6 10.3 No No
10 empty 1.7 60.6 10.8 No No
4HAX_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 51.4 29.9 Yes No
2 bound 2.46 66.1 25.1 No No
3 empty 1.58 57.3 18.2 No No
4 empty 2.29 58.2 20.4 No No
5 bound 1.96 74.8 13.1 No No
6 empty 2.08 54.2 14 No No
7 empty 1.99 52 13.3 No No
8 bound 2.1 97.9 0 Yes No
9 empty 2.21 64.7 9.9 No No
10 empty 2.42 56.7 10.2 No No
5CJ2_H GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 63.7 36.5 Yes No
2 empty 2.39 62.1 26.2 No No
3 empty 2.32 61.1 21.2 No No
4 empty 2.35 61.1 23.3 No No
5 bound 2.35 71 11.9 No No
6 empty 2.44 65.3 14 No No
7 empty 1.83 62.3 9.1 No No
8 empty 2.03 64.9 8.4 No No
9 bound 1.68 73.4 10.5 No No
10 empty 2.11 65.4 7.6 No No
5YTB_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 52.7 29.3 Yes No
2 bound 2.34 63.9 24.9 No No
3 empty 1.51 57.5 18.9 No No
4 empty 2.32 59.1 20.5 No No
5 bound 1.84 72.4 13 No No
6 empty 2.09 56.8 12.7 No No
7 empty 2.06 51.9 11.7 No No
8 empty 2.05 57.1 14.1 No No
9 empty 2.73 54.5 11.3 No No
10 empty 1.52 48 10.5 No No
3NBZ_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 70.4 37 Yes No
2 empty 2.58 60.3 24.4 No No
3 empty 2.03 65.1 16.2 No No
4 empty 2.43 65 22.8 No No
5 empty 2.09 55.3 19 No No
6 empty 1.98 65.2 15.7 No No
7 empty 2.27 75 10.1 No No
8 empty 2.23 59.7 11.5 No No
9 empty 2.27 58 8.7 No No
10 empty 2.89 76.4 6.2 No No
4GMX_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 52.4 29.8 Yes No
2 bound 2.3 65.1 27.5 No No
3 empty 1.6 59 18.6 No No
4 empty 2.31 58.6 19.2 No No
5 bound 1.71 75.1 10.6 No No
6 empty 2.12 58.4 11.2 No No
7 empty 1.86 41.5 14.8 No No
8 empty 2.13 53.4 12.8 No No
9 bound 2.38 97.1 0 Yes No
10 empty 2.04 50.8 11.9 No No
3GJ5_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 65.8 45.6 Yes No
2 empty 2.45 64.4 25.6 No No
3 empty 2.26 63.7 18.8 No No
4 empty 2.1 62.4 23.1 No No
5 bound 1.98 73.2 12.5 No No
6 empty 1.78 63.9 12.8 No No
7 empty 2.18 75.3 12.1 No No
8 empty 2.41 64.7 16.9 No No
9 bound 1.81 80.7 9.4 No No
10 empty 1.91 61.1 8.3 No No
6Q84_E GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 73.4 36.6 Yes Yes
2 empty 2.23 62.7 23 No No
3 empty 2.01 54.7 14.7 No No
4 empty 2.35 73.3 9.2 No No
5 empty 2.08 58.5 10.1 No No
6 empty 2.55 64.7 12 No No
7 empty 2.41 63.1 10 No No
8 empty 2.64 56.6 14.1 No No
9 empty 2.48 67.7 9.1 No No
10 empty 2.39 58.3 10.4 No No
4HAV_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 64.7 53.2 Yes No
2 empty 1.83 61.8 23.9 No No
3 empty 2.56 61.2 21.2 No No
4 empty 1.67 53.2 15.9 No No
5 empty 2.03 56.9 15.9 No No
6 empty 2.8 57.7 11.7 No No
7 empty 2.18 70.4 9.7 No No
8 empty 2.42 68.1 14.8 No No
9 empty 2.15 59.4 7.5 No No
10 empty 2.34 62.7 14.1 No No
6A3E_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 64.5 51.1 Yes No
2 empty 2.64 59.2 27 No No
3 empty 1.92 61.6 25.4 No No
4 empty 1.98 56.7 12 No No
5 empty 2.22 56.2 12.1 No No
6 empty 1.56 56.4 15.6 No No
7 empty 2.17 66.4 10.7 No No
8 empty 2.24 58.3 10.4 No No
9 empty 1.94 59.1 10 No No
10 empty 1.45 52.1 11.5 No No
3NBY_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.05 72.1 38.6 Yes Yes
2 empty 2.59 61.6 25.8 No No
3 empty 1.99 66.7 17.8 No No
4 empty 2.42 66.6 21 No No
5 empty 2.03 65.4 19.4 No No
6 empty 2.34 61.1 15.2 No No
7 empty 2.4 62.4 12.8 No No
8 empty 1.68 63.1 13.2 No No
9 empty 2.7 57.7 6.9 No No
10 empty 3.02 46.2 7.3 No No
4GPT_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 63.7 36.3 Yes No
2 bound 2.46 69.4 29.7 No No
3 empty 2.55 62.1 19.3 No No
4 empty 1.62 63.3 18.7 No No
5 empty 2.08 54.1 13.2 No No
6 empty 2.36 51.7 16.4 No No
7 empty 2.13 64.6 11.3 No No
8 empty 2.31 54.5 11 No No
9 empty 1.89 53.4 12 No No
10 empty 1.91 67.2 13.2 No No
4HB2_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 49 29.4 Yes No
2 bound 2.39 65.1 26.2 No No
3 empty 1.51 57.9 18 No No
4 empty 2.3 59.9 19.4 No No
5 bound 1.77 74.8 11 No No
6 empty 2.12 44.6 15.2 No No
7 empty 1.95 55.1 14 No No
8 empty 2.11 56.7 10.3 No No
9 empty 1.91 50.2 13.1 No No
10 empty 1.91 67.5 9.8 No No
3EA5_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 69.2 22.9 No No
2 bound 2.12 79.9 25.9 Yes Yes
3 empty 2.5 58.8 34.1 No No
4 empty 2.08 63.4 32.5 No No
5 empty 1.96 67.2 10.4 No No
6 empty 2.3 62.7 13.9 No No
7 empty 2.37 59 12 No No
8 empty 2.29 66.4 7.4 No No
9 empty 1.88 55.1 8.7 No No
10 empty 2.5 69.8 0 No No
5CIW_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 62.7 38.2 Yes No
2 empty 2.22 62.7 28.6 No No
3 empty 2.13 60 30.6 No No
4 bound 2.08 71.2 17.8 No No
5 empty 2.13 67.7 14.9 No No
6 empty 2.13 61.9 17.3 No No
7 empty 2.12 64.8 10.1 No No
8 empty 1.94 61.8 8.8 No No
9 empty 1.87 59.7 11.4 No No
10 empty 2.36 69.5 14.3 No No
4HAU_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 64 36.9 Yes No
2 bound 2.6 70.2 28.4 No No
3 empty 2.62 58.8 27.6 No No
4 empty 1.76 55.5 17.3 No No
5 empty 2.06 59.1 14.9 No No
6 empty 2.12 56.3 11.8 No No
7 empty 2.53 55.7 11.8 No No
8 empty 2.41 58.7 8 No No
9 empty 1.78 49.7 8.9 No No
10 empty 2.29 68.3 9.6 No No
5UWT_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 55.7 30.2 Yes No
2 bound 2.27 61 27.7 No No
3 empty 1.52 58.4 18.9 No No
4 empty 2.32 58 19.4 No No
5 empty 1.63 48.7 11.9 No No
6 empty 1.95 52.4 13.5 No No
7 empty 2.25 53.6 11.9 No No
8 empty 1.37 53.9 11.3 No No
9 empty 1.66 54.2 10.1 No No
10 empty 2.41 47.1 13.2 No No
5YRO_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 50.7 29.7 Yes No
2 bound 2.21 63.5 29.2 No No
3 empty 1.56 58.6 17.8 No No
4 empty 2.24 58.1 19.5 No No
5 bound 1.81 77.9 11.5 No No
6 empty 1.65 55.4 10.6 No No
7 empty 2.05 57.1 12.5 No No
8 empty 2.64 54.4 12.2 No No
9 empty 2.12 52.1 12.6 No No
10 empty 1.21 55.8 10.1 No No
4HAT_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 53 29.5 Yes No
2 bound 2.29 63.5 28.6 No No
3 empty 1.56 61.9 17.8 No No
4 empty 2.3 60.9 19.5 No No
5 bound 1.94 77.2 13.5 No No
6 empty 2.18 54.6 12.4 No No
7 empty 2.02 52.1 12.7 No No
8 empty 2.58 52.5 11.3 No No
9 bound 2.22 99.3 0 Yes No
10 empty 1.74 65.3 8.8 No No
5DIS_B GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 73 41.1 Yes Yes
2 empty 2.42 59.5 21.5 No No
3 empty 1.93 60.2 15.8 No No
4 empty 1.99 56.6 17 No No
5 empty 1.98 61.2 15.3 No No
6 empty 2.41 58.1 11 No No
7 empty 1.96 66.9 11 No No
8 empty 2.39 63.2 11 No No
9 empty 2.49 63 8.6 No No
10 empty 2.6 67.4 11.2 No No
5BXQ_E GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 66.5 35.1 Yes Yes
2 bound 2.22 65.2 23.1 No No
3 empty 2.27 59.8 19.6 No No
4 empty 1.9 61.3 13.4 No No
5 bound 2.2 69.2 11.9 No No
6 empty 2.05 67 12.4 No No
7 empty 2.21 62 14.4 No No
8 empty 1.76 60.5 13.4 No No
9 bound 1.69 75.2 10.8 No No
10 empty 1.92 77.9 9.3 No No
1IBR_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 72.8 35.8 Yes No
2 empty 2.51 58.2 26.1 No No
3 empty 2.2 66.8 12.6 No No
4 empty 2.43 63.3 23.5 No No
5 empty 2.15 62.5 15.8 No No
6 empty 1.53 63.5 9.2 No No
7 empty 2.09 59.2 8.2 No No
8 empty 2.66 82.4 0 No No
9 empty 1.49 62.4 9.9 No No
10 empty 2.25 56.2 6.2 No No
1K5G_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 51 31 Yes No
2 bound 2.11 73.4 29.6 No No
3 empty 1.47 61.6 17.5 No No
4 empty 2.41 62.2 26.7 No No
5 empty 1.8 52.8 13.1 No No
6 empty 2.17 63.1 10.6 No No
7 empty 1.27 60.3 10.2 No No
8 empty 2.44 60.3 15.9 No No
9 empty 1.99 68 12.5 No No
10 empty 2.18 53.3 12.2 No No
2N1B_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 67.7 36 Yes No
2 empty 2.2 59.8 19.9 No No
3 empty 1.98 63.8 23.1 No No
4 empty 1.91 73.3 12.8 No No
5 empty 2.18 73.6 13.3 No No
6 empty 2.3 66.9 15.2 No No
7 empty 2.08 56.6 16.8 No No
8 empty 2.47 79.2 9.8 No No
9 empty 1.94 68.2 9.9 No No
10 empty 1.99 67.3 10.5 No No
4C0Q_D GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 66.6 25.6 Yes No
2 bound 2.06 80.3 20.1 Yes Yes
3 empty 2.27 62.6 19.5 No No
4 empty 2.15 64.3 16.2 No No
5 empty 2.18 63.7 21.8 No No
6 empty 1.34 67 14.8 No No
7 empty 2.37 57.9 10.9 No No
8 empty 2.34 62.7 19.9 No No
9 empty 2.24 58.5 13.3 No No
10 empty 2.52 56.2 9.6 No No
5CJ2_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 60.8 27.4 Yes No
2 empty 2.18 60.1 28.6 No No
3 empty 2.17 65 16.3 No No
4 empty 2.16 65.8 17.7 No No
5 empty 2.23 62.5 17.6 No No
6 bound 2.09 70.2 11.3 No No
7 empty 2.4 66.1 22.8 No No
8 empty 1.93 66.8 10 No No
9 empty 1.99 68 13.2 No No
10 bound 1.77 70.4 10.8 No No
3ZJY_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 72.6 33.1 Yes No
2 empty 2.06 73.2 27.2 No No
3 empty 1.69 73.2 23.3 No No
4 empty 2.07 54.6 16.9 No No
5 empty 2.14 60.6 13.5 No No
6 empty 1.95 70.7 10.5 No No
7 empty 1.5 98.2 0 Yes No
8 empty 2.12 59.5 10.8 No No
9 empty 2.55 55.4 10 No No
10 empty 2.95 69.8 5.9 No No
3GJ4_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.46 62.5 24.3 Yes No
2 empty 2.42 68.6 21.8 No No
3 empty 2.25 66.1 20.5 No No
4 empty 2.35 68.2 18 No No
5 empty 2.1 60.5 22 No No
6 empty 2.4 63 22.2 No No
7 bound 2.09 77.9 10.8 No No
8 empty 2.39 56.5 15.1 No No
9 empty 2.15 70.2 13.1 No No
10 empty 2.03 75.3 11.8 No No
4HB4_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 63.9 35.5 Yes No
2 bound 2.56 67.5 29.7 No No
3 empty 2.5 60.4 26 No No
4 empty 1.86 60.8 22.7 No No
5 empty 1.63 53.7 19 No No
6 empty 2.17 57.7 13.4 No No
7 empty 2.16 57.5 11.4 No No
8 empty 2.67 57.3 11.9 No No
9 empty 1.83 55.8 9.9 No No
10 empty 1.92 60.4 14.1 No No
1RRP_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 71.5 38.8 Yes No
2 empty 1.95 62.8 29.9 No No
3 empty 2.23 51.1 20.9 No No
4 empty 2.24 61.4 24.1 No No
5 empty 1.74 60 16.9 No No
6 empty 2.13 59.5 12.7 No No
7 empty 1.62 60.2 14.6 No No
8 empty 2.53 53.1 11.4 No No
9 empty 1.65 50.6 9.1 No No
10 empty 2.38 63 9.7 No No
5DLQ_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 74.7 30.9 Yes No
2 empty 2.4 61.9 33.3 No No
3 empty 2.14 58.5 14.3 No No
4 empty 2.08 61.5 15 No No
5 empty 2.26 57.9 15.9 No No
6 empty 2.47 53.8 8.4 No No
7 empty 2.31 74.5 8.5 No No
8 empty 1.92 53 11.1 No No
9 empty 2.16 38.7 11.1 No No
10 empty 2.48 68.5 9.5 No No
5BXQ_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 63.6 28.2 Yes No
2 empty 2.36 67.8 13.7 No No
3 empty 2.31 67.3 18.4 No No
4 empty 2.06 63.9 15.3 No No
5 bound 2.14 71.6 12.5 No No
6 empty 1.96 59 12.8 No No
7 empty 1.92 62.2 11.6 No No
8 bound 1.69 77.1 10.2 No No
9 empty 2.31 71 11.9 No No
10 empty 1.95 66.8 11.2 No No
3GJX_F GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 67 35.8 Yes No
2 empty 2.39 56.8 21.7 No No
3 empty 1.84 62.2 15.7 No No
4 empty 2.09 54.8 15.6 No No
5 empty 1.97 59.9 12.1 No No
6 empty 2.22 53.8 13 No No
7 empty 2.09 67.8 8.7 No No
8 empty 1.98 68.3 10.4 No No
9 empty 1.72 41.7 9.7 No No
10 empty 2.43 51 9.5 No No
3NC0_F GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 75.1 35.5 Yes No
2 empty 2.43 56.6 21.5 No No
3 empty 2.05 65.6 16 No No
4 empty 2.13 58.5 14.6 No No
5 empty 2.01 62.9 16.6 No No
6 empty 2.02 77.4 0 No No
7 empty 2.37 67.3 16.7 No No
8 empty 2.1 71.8 10 No No
9 empty 2.33 62.7 11.4 No No
10 empty 2.69 67.2 11.7 No No
5UWI_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 52 29 Yes No
2 bound 2.4 68.7 26.1 No No
3 empty 2.58 60.8 26.2 No No
4 bound 2.09 82.7 24 No No
5 empty 1.78 61.3 21.3 No No
6 empty 2.08 58.8 15.7 No No
7 empty 2.12 55.1 14.4 No No
8 empty 1.8 54.5 10.7 No No
9 empty 1.47 51.3 14.9 No No
10 empty 1.62 52.4 12.7 No No
5UWQ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 63.9 36.9 Yes No
2 bound 2.37 68.3 29.8 No No
3 empty 2.38 58.5 25 No No
4 empty 1.54 61.2 17.7 No No
5 empty 1.83 40.9 16.8 No No
6 empty 2.05 58.5 15.9 No No
7 empty 2.04 57 13.1 No No
8 empty 1.69 59.2 10 No No
9 empty 1.58 52.7 12.2 No No
10 empty 2.26 59 17.5 No No
1K5D_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 71.3 30.5 Yes No
2 empty 2.28 50.8 22.1 No No
3 empty 2.43 63.3 31.1 No No
4 empty 1.92 62.7 24.8 No No
5 empty 2.16 59.9 10.5 No No
6 empty 1.75 52.8 14.7 No No
7 empty 2.32 48.5 22.4 No No
8 empty 1.22 58 10.4 No No
9 empty 2.22 57.6 10 No No
10 empty 1.72 65.5 9.5 No No
1K5D_D GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 53.5 22.6 No No
2 empty 2.5 61.7 31.6 No No
3 bound 2.07 81.5 20.4 No No
4 empty 1.84 61.7 24.6 No No
5 empty 2.06 62.1 15 No No
6 empty 2.14 62.4 13.3 No No
7 empty 1.72 52.1 13 No No
8 empty 1.22 57.4 10.2 No No
9 empty 2.09 65.3 8.8 No No
10 empty 2.51 58.7 10.3 No No
3EA5_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 76.1 35.2 Yes No
2 empty 2.11 65.1 32 No No
3 empty 1.88 59.6 15.4 No No
4 empty 2.4 60.7 20.1 No No
5 empty 2.48 61.2 11.1 No No
6 empty 2.2 60.6 17.5 No No
7 empty 2.21 57.9 12.3 No No
8 empty 2.18 61.2 13.3 No No
9 empty 2.28 55.5 15.3 No No
10 empty 2.4 64.5 10.5 No No
6Q84_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 71.6 24.7 Yes No
2 empty 2.47 68 24.9 No No
3 empty 2.32 64.3 22.2 No No
4 empty 1.91 58.7 16.3 No No
5 empty 2.39 72 8.8 No No
6 empty 2.43 60.8 11.2 No No
7 empty 2.08 57.1 12 No No
8 empty 2.37 60.7 10.1 No No
9 empty 2.22 54.5 9.4 No No
10 empty 2.37 55 11 No No
5CJ2_F GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.62 65.2 19.8 No No
2 empty 2.5 65.3 17.2 No No
3 empty 2.21 62.7 22.1 No No
4 empty 2.24 63.2 20.6 No No
5 bound 2.03 70.9 14.5 No No
6 empty 1.95 60.1 18 No No
7 empty 2 65.2 12.6 No No
8 empty 2.33 68.1 9.6 No No
9 empty 1.97 72.1 11.1 No No
10 empty 1.99 65.1 10.8 No No
1IBR_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 74.7 34.9 Yes Yes
2 empty 2.44 59.4 23.9 No No
3 empty 2.14 63.3 14 No No
4 empty 2.17 62.5 13.4 No No
5 empty 2.58 67.2 12.1 No No
6 empty 1.66 64.2 12.9 No No
7 empty 2.33 61.7 11 No No
8 empty 2.49 64.9 8.4 No No
9 empty 2.43 75.8 8.1 No No
10 empty 2.27 60.5 7.9 No No
6A38_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 50.5 29.9 Yes No
2 bound 2.33 64.6 26.5 No No
3 empty 1.55 59.6 19.2 No No
4 empty 2.29 58.5 21.1 No No
5 bound 1.93 79.8 12.6 No No
6 empty 2.68 50.7 11.7 No No
7 empty 2.23 52.4 11.3 No No
8 empty 1.97 54.6 11.2 No No
9 bound 2.19 98 0 Yes No
10 empty 2.41 61.2 9.7 No No
1I2M_C GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 56.1 18.4 No No
2 empty 2.54 65.8 22 No No
3 empty 2.12 62.7 21 No No
4 empty 2.12 67.1 22.4 No No
5 empty 2.28 66 14.7 No No
6 empty 2.14 65.1 16.1 No No
7 empty 2.24 69.9 11.4 No No
8 bound 2.55 68.5 12.7 No No
9 empty 2.25 71 11.7 No No
10 empty 2.51 64.2 8.5 No No
1K5D_J GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 51.3 21.7 No No
2 bound 2.14 70.8 31.6 No No
3 empty 2.5 62 27.1 No No
4 empty 1.58 61.6 21.3 No No
5 empty 2.18 60.7 11.6 No No
6 empty 1.85 51.3 17 No No
7 empty 1.72 63.3 12 No No
8 empty 2.63 58.9 10.3 No No
9 empty 1.68 59.2 9.9 No No
10 empty 2.31 53.4 9.1 No No
1K5G_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 53.5 27 Yes No
2 bound 2.08 72.6 30.3 No No
3 empty 1.5 63.7 18.7 No No
4 empty 2.48 62.5 21.8 No No
5 empty 1.81 50.8 12.7 No No
6 empty 2.16 58.4 13.8 No No
7 empty 1.38 57 10.6 No No
8 empty 2.23 61.4 11.2 No No
9 empty 1.69 62.7 13.3 No No
10 empty 2.14 52.2 15.8 No No
5UWP_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 49.9 29.7 Yes No
2 bound 2.35 61.4 27 No No
3 empty 2.31 58 22.5 No No
4 empty 1.52 57.8 19.4 No No
5 bound 1.74 74.1 13 No No
6 empty 1.87 50.3 12.2 No No
7 empty 2.28 59.3 12.3 No No
8 empty 2.22 58.5 11.5 No No
9 empty 1.73 51 10.8 No No
10 empty 1.1 48 11.6 No No
2MMC_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 65.7 31.2 Yes No
2 empty 2.57 65.6 19.5 No No
3 empty 2.26 64 18.5 No No
4 empty 2.28 63.6 20.3 No No
5 empty 2.09 62.5 21.5 No No
6 empty 2.15 72.1 10.6 No No
7 empty 2.55 86.5 9.5 Yes No
8 empty 2.19 65.3 10.7 No No
9 empty 2.05 72.9 11.4 No No
10 empty 1.92 68.9 10.2 No No
5UWU_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 52.1 29.9 Yes No
2 bound 2.32 63.2 28 No No
3 empty 1.53 58.5 18.3 No No
4 bound 1.57 76.3 13.4 No No
5 empty 2.37 50.9 20.9 No No
6 empty 2.42 69 12.3 No No
7 empty 2.19 53.6 13.4 No No
8 empty 1.55 46.6 17 No No
9 empty 2.09 52.6 12.5 No No
10 empty 2.28 47.7 12.1 No No
5CLQ_C GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 47.3 20.5 No No
2 bound 2.1 75 21.3 No No
3 empty 2.48 65.3 27.9 No No
4 empty 1.66 61 21.6 No No
5 empty 2.15 58.4 17 No No
6 empty 1.98 61.9 16.1 No No
7 empty 1.79 54.9 17.9 No No
8 empty 2.26 61.5 18.1 No No
9 empty 1.9 54.9 8.3 No No
10 empty 2.62 57.6 11.8 No No
5CJ2_G GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 68.9 15.9 No No
2 empty 2.45 66.7 23.8 No No
3 empty 2.25 64.7 22 No No
4 empty 2.15 62.7 21.6 No No
5 bound 2.16 69 15.2 No No
6 empty 1.97 56.1 14.1 No No
7 empty 2.5 59.8 15.6 No No
8 bound 1.67 76.4 9.9 No No
9 empty 2.04 67.7 12.1 No No
10 empty 2.02 66.2 9.6 No No
1A2K_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 59.8 35.1 Yes No
2 empty 2.64 65.6 23.4 No No
3 empty 2.17 66.7 20.5 No No
4 empty 2.01 61.5 20 No No
5 bound 2.1 73.9 19.7 No No
6 empty 2.07 65.7 17 No No
7 empty 1.37 77.8 13.5 No No
8 empty 2.17 62.1 17.3 No No
9 empty 1.98 71.4 11.3 No No
10 empty 1.98 63.3 8.9 No No
6A3B_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 49.6 30.2 Yes No
2 bound 2.34 62.5 27.9 No No
3 empty 2.3 56 22.2 No No
4 empty 1.51 60.2 18.7 No No
5 bound 1.77 76.1 10.5 No No
6 empty 2.12 54.8 13.8 No No
7 empty 1.94 49.6 12.7 No No
8 empty 2.62 52.3 11.4 No No
9 bound 2.15 99.4 0 Yes No
10 empty 2.07 56.7 9.4 No No
3GJ0_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 65.5 35.1 Yes No
2 empty 2.29 60 17.6 No No
3 bound 2.13 72 15 No No
4 empty 1.97 59.3 13.1 No No
5 empty 2.31 67.8 14 No No
6 empty 2.46 68.3 10.6 No No
7 empty 2.66 75.3 16.7 No No
8 empty 2.2 72.2 13.5 No No
9 empty 2.35 61.7 10.3 No No
10 empty 1.86 66 9.1 No No
2MMG_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 65.6 31.9 Yes No
2 empty 1.63 58.6 24.4 No No
3 empty 2.4 59.3 22.2 No No
4 empty 2.1 59 19.5 No No
5 empty 2.48 67.8 18.4 No No
6 empty 2.03 67.9 13.3 No No
7 empty 2.37 60.3 13.7 No No
8 empty 2.18 56.4 15.7 No No
9 empty 2.04 60.9 15.5 No No
10 empty 2.51 61.5 13.6 No No
5DI9_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 49.6 29.5 Yes No
2 bound 2.29 61 26.9 No No
3 empty 2.38 55.6 27 No No
4 empty 1.53 56.9 19.2 No No
5 bound 1.8 76.1 12.4 No No
6 empty 2.18 57 12.7 No No
7 empty 2.06 52.4 12 No No
8 empty 1.55 46.3 9.5 No No
9 empty 1.69 52.5 10.3 No No
10 empty 1.97 53.1 10.9 No No
4HAY_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 63.6 36.2 Yes No
2 bound 2.53 66.1 28.9 No No
3 empty 1.98 63.8 26.8 No No
4 empty 2.62 59.8 27 No No
5 empty 1.71 51.4 17.1 No No
6 empty 2.1 57.7 14.7 No No
7 empty 2.08 56.1 18 No No
8 empty 2.29 55.2 11.6 No No
9 empty 2.28 63.6 14.5 No No
10 empty 1.61 24.4 9.8 No No
1K5D_G GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 50.3 22.2 No No
2 bound 2.08 71.6 34.5 No No
3 empty 1.9 59.5 27.3 No No
4 empty 2.48 61 23.3 No No
5 empty 2.16 57.1 13.4 No No
6 empty 1.93 55.7 18.9 No No
7 empty 2.15 64.7 13.3 No No
8 empty 2.62 58.2 11 No No
9 empty 2.21 60.2 9.6 No No
10 empty 2.41 72.2 7.5 No No
5DIF_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 50.7 30.2 Yes No
2 bound 2.33 61.4 27.2 No No
3 empty 1.57 58.7 18.3 No No
4 empty 2.29 59 21.3 No No
5 bound 1.7 73.3 13.7 No No
6 empty 2.12 57.5 12.7 No No
7 empty 1.64 52.9 11.9 No No
8 empty 2.03 50.8 11.3 No No
9 empty 2.49 50.2 11.5 No No
10 empty 1.61 48.5 9.9 No No
3GJ7_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 75.9 19.8 Yes No
2 empty 2.44 65.9 22 No No
3 empty 2.11 61.1 18.7 No No
4 empty 1.95 61.5 17.1 No No
5 empty 2.1 63.7 20.1 No No
6 empty 2.1 61 20.6 No No
7 bound 1.93 69.7 10.4 No No
8 empty 2.19 76.9 12 No No
9 empty 2.12 64.9 11.9 No No
10 bound 1.7 72.5 10.7 No No
3NC1_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.06 73 39.8 Yes Yes
2 empty 2.56 61.2 26.4 No No
3 empty 2 60.6 17.8 No No
4 empty 2.08 58.9 17.7 No No
5 empty 2.08 61.5 16.6 No No
6 empty 2.14 72 10.1 No No
7 empty 1.85 62.9 17.2 No No
8 empty 2.37 60.5 10.2 No No
9 empty 2.13 62.4 12.1 No No
10 empty 2.38 61.1 10.2 No No
5JLJ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 52.2 30.3 Yes No
2 bound 2.4 66 24.8 No No
3 empty 1.44 57.5 18.3 No No
4 empty 2.28 58.9 20.6 No No
5 bound 1.69 71.4 10.8 No No
6 empty 2.24 57.2 11.5 No No
7 empty 1.58 33.6 14 No No
8 empty 2.03 53.7 12.2 No No
9 empty 2.09 55.6 9.1 No No
10 bound 2.11 97.1 0 Yes No
5CLL_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 71.3 33.6 Yes No
2 empty 1.93 63.9 25.3 No No
3 empty 2.43 57.6 26 No No
4 empty 1.7 55.4 16.2 No No
5 empty 2.14 63.6 10.1 No No
6 empty 2.22 61.2 13.7 No No
7 empty 2.23 61.6 14.1 No No
8 empty 2.09 61.7 12.3 No No
9 empty 2.04 53.2 9.7 No No
10 empty 2.03 57.8 8.9 No No
3W3Z_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 70.2 38.5 Yes No
2 empty 2.54 63.2 30.8 No No
3 empty 2.08 64.3 24.2 No No
4 empty 2.21 66.5 11.1 No No
5 empty 2.43 58.4 15 No No
6 empty 2.34 60.6 10.8 No No
7 empty 2.4 57.9 10.7 No No
8 empty 1.88 59.6 8.5 No No
9 empty 2.39 57.6 7.4 No No
10 empty 2.24 63.6 11.1 No No
3GJ8_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 67.3 39.3 Yes Yes
2 empty 2.47 65.1 25.8 No No
3 empty 2.22 66.8 18.1 No No
4 empty 2.45 60.2 18.1 No No
5 empty 2.4 67.8 16.5 No No
6 bound 2.11 70.6 12.2 No No
7 empty 2.4 61.3 11.3 No No
8 empty 2.15 77.5 10.6 No No
9 empty 2.35 66.8 10.8 No No
10 bound 1.75 73.5 10.5 No No
5YU6_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 72.7 38.4 Yes No
2 empty 2.33 58.8 26 No No
3 empty 2.1 61.5 15.9 No No
4 empty 2.24 66.6 12.4 No No
5 empty 1.94 65.2 18.2 No No
6 empty 2.49 69 10 No No
7 empty 2.03 57.5 11.9 No No
8 empty 2.51 54.3 12 No No
9 empty 2.24 56.1 12.9 No No
10 empty 2.61 65.5 8.3 No No
5UWH_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 52.1 29.6 Yes No
2 bound 2.33 64.6 26 No No
3 empty 1.57 58.1 18.1 No No
4 empty 2.3 57.6 20 No No
5 bound 1.69 74.5 16 No No
6 empty 1.47 33.1 16.8 No No
7 empty 1.92 52.6 13.4 No No
8 empty 2.37 54.3 10.2 No No
9 empty 2.41 51 11.1 No No
10 empty 2.34 53.8 11.4 No No
1RRP_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 71.1 37.5 Yes No
2 empty 2.02 63.1 30.4 No No
3 empty 2.31 60.1 28.5 No No
4 empty 1.73 63.7 15.7 No No
5 empty 2.11 59.3 11.7 No No
6 empty 2.25 53.2 15.1 No No
7 empty 1.64 48.6 8.2 No No
8 empty 1.29 63.2 7 No No
9 empty 2.32 62.1 11.5 No No
10 empty 2.58 62 6.3 No No
5UWR_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 54.1 30.9 Yes No
2 bound 2.46 67.7 24.9 No No
3 empty 2.41 59.9 25.5 No No
4 bound 2.11 83.4 21.1 No No
5 empty 1.57 60.7 18.3 No No
6 empty 1.65 40.3 14.8 No No
7 empty 2.06 61.1 15.6 No No
8 empty 2.13 56.9 15.6 No No
9 empty 2.63 57.1 10.5 No No
10 empty 1.74 58.7 10.6 No No
5DLQ_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 76.5 32 Yes No
2 empty 2.29 61 19.8 No No
3 empty 2.07 57 14.2 No No
4 empty 2.11 56.4 13.4 No No
5 empty 1.58 67.6 10.6 No No
6 empty 2.38 56.5 14 No No
7 empty 2.12 58.9 12.9 No No
8 empty 2.37 55.4 10.1 No No
9 empty 2.29 59.2 9.1 No No
10 empty 2.32 65 7.2 No No
5CJ2_C GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 65.8 18.1 No No
2 empty 2.21 65.1 32 No No
3 empty 2.14 64.8 25 No No
4 bound 2.1 71.7 19.1 No No
5 empty 2.24 62.1 18.5 No No
6 empty 2.38 67.6 18.9 No No
7 empty 2.34 66.1 13.7 No No
8 empty 2.4 58.7 12.5 No No
9 empty 1.87 63.1 9.8 No No
10 empty 2.32 63.6 11.7 No No
5UWS_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 49.8 29 Yes No
2 bound 2.31 66.9 27.9 No No
3 empty 2.29 55.9 23.2 No No
4 empty 1.58 56.5 18.5 No No
5 bound 1.52 77.3 13.9 No No
6 empty 1.56 39.4 12.6 No No
7 bound 2.19 53.1 12.4 No No
8 empty 2.04 55.3 12.5 No No
9 bound 2.14 96 0 Yes No
10 empty 1.93 57 10.8 No No
5UWJ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 50 29.9 Yes No
2 bound 2.27 61.6 26.9 No No
3 empty 1.51 56.9 18.5 No No
4 bound 1.75 73.5 15.2 No No
5 empty 2.32 51.3 20 No No
6 empty 2.46 69.6 11.4 No No
7 empty 1.74 45.2 12.2 No No
8 empty 2.2 54.4 13.5 No No
9 empty 2.04 51.2 12.2 No No
10 empty 1.96 49.8 11.5 No No
5YSU_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 52 32.5 Yes No
2 bound 2.31 61.2 26.2 No No
3 empty 1.57 57.8 18.6 No No
4 empty 2.32 60.4 20.3 No No
5 bound 1.61 76.2 11 No No
6 empty 2.16 54.1 12.4 No No
7 empty 1.94 52.5 14.5 No No
8 empty 2.37 52.1 11 No No
9 empty 2.32 56.9 9 No No
10 empty 2.01 60 10.2 No No
1QBK_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 56.8 28.4 Yes No
2 empty 2.23 67.1 30.5 No No
3 empty 2.48 60.3 26.5 No No
4 bound 2.32 81.2 21.1 No No
5 empty 2.39 55 15.7 No No
6 empty 1.88 67.1 11.2 No No
7 empty 2.07 70 8.2 No No
8 empty 2.45 63.8 10.7 No No
9 empty 2.21 70 7.5 No No
10 empty 2.03 49.2 14.4 No No
5CJ2_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 63.5 28.1 Yes No
2 empty 2.48 63.8 21.4 No No
3 empty 2.18 65 18.9 No No
4 empty 2.22 64.3 17.5 No No
5 empty 2.33 61.3 25.8 No No
6 bound 2 70.8 11.8 No No
7 empty 2.38 64 22.1 No No
8 empty 1.96 64.7 18.7 No No
9 empty 1.78 63.7 12.7 No No
10 empty 2.34 73.1 16.5 No No
5CIT_B GTP-binding nuclear protein Ran No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 62.5 20.9 No No
2 empty 2.27 65.1 15.6 No No
3 empty 2.1 60 18.7 No No
4 empty 2.2 64.5 17.2 No No
5 empty 2.07 61.3 14.3 No No
6 bound 1.89 74.6 10.4 No No
7 bound 1.76 81.1 9.9 No No
8 empty 1.86 61 14.3 No No
9 empty 1.99 77.9 9.1 No No
10 empty 2.52 53.9 10.1 No No
3A6P_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 73.4 38.2 Yes No
2 empty 2.59 59.6 28 No No
3 empty 1.97 64.2 12.4 No No
4 empty 2.25 60.6 15.5 No No
5 empty 2 67.1 17.4 No No
6 empty 2.33 56.6 11.8 No No
7 empty 2.11 58.2 10.4 No No
8 empty 2.33 61.9 11.4 No No
9 empty 2.25 61.3 12.3 No No
10 empty 2.47 71.4 10.1 No No
3NC0_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 75.6 38 Yes No
2 empty 2.44 58.1 20.2 No No
3 empty 1.99 64.9 15.9 No No
4 empty 2.02 61.3 16.1 No No
5 empty 1.97 67.7 17.6 No No
6 empty 2.04 70.4 10.5 No No
7 empty 2.11 72.6 15.6 No No
8 empty 2.12 75.5 0 No No
9 empty 2.58 63.8 8.7 No No
10 empty 1.87 56 8.6 No No
5DH9_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 63.9 38 Yes No
2 bound 2.48 70 29.6 No No
3 empty 1.78 59.4 20.9 No No
4 empty 2.44 58.8 26.6 No No
5 empty 1.6 33.5 13.8 No No
6 empty 2.08 59.3 15 No No
7 empty 2.04 56.4 15.7 No No
8 empty 2.66 58.4 11.8 No No
9 empty 1.79 57.6 9.6 No No
10 empty 1.64 54.1 11.5 No No
5YST_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 52.7 31.7 Yes No
2 bound 2.2 62.9 28.2 No No
3 empty 1.49 59.6 19.3 No No
4 empty 2.34 59.5 19.9 No No
5 bound 1.74 76 13.4 No No
6 empty 2.22 54.7 12.7 No No
7 empty 2.02 52 12 No No
8 empty 2.71 55.7 11.8 No No
9 empty 1.87 52.3 12.5 No No
10 bound 2.04 98.6 0 Yes No
3GJ7_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 63.2 38.4 Yes No
2 empty 2.35 65.4 31.3 No No
3 empty 2.19 62.6 15.9 No No
4 bound 1.93 77.8 20.1 No No
5 empty 2.32 61.9 18.9 No No
6 empty 1.93 60.1 12.2 No No
7 empty 1.87 70.2 20.5 No No
8 empty 2.13 65.6 13.6 No No
9 empty 2 76.9 9.8 No No
10 empty 2.06 63.1 8.4 No No
5UWW_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 62 37.9 Yes No
2 bound 2.53 69.6 28.6 No No
3 empty 2.5 60.7 33 No No
4 empty 1.81 60.6 24 No No
5 empty 1.72 45.7 13.5 No No
6 empty 2.07 58.1 15.4 No No
7 empty 2.04 55.9 16.1 No No
8 empty 2.82 56.7 12 No No
9 empty 2.21 59.4 15 No No
10 empty 1.59 52.9 12.6 No No
3ZJY_D GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.11 72.4 40.9 Yes Yes
2 empty 1.95 80.2 21.6 Yes Yes
3 empty 2.19 68.2 20.8 No No
4 empty 2.52 58.8 10.5 No No
5 empty 1.58 100 0 Yes No
6 empty 2.3 70.2 5.6 No No
7 empty 2.43 54.5 5.6 No No
8 empty 1.97 68.4 6 No No
9 empty 2.72 65.5 4.8 No No
4OL0_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 69.6 39.5 Yes No
2 empty 2.03 70.3 16.4 No No
3 empty 2.22 59.8 33.4 No No
4 empty 2.06 53.8 13.5 No No
5 empty 2.23 58.8 11.8 No No
6 empty 2.45 61 10.4 No No
7 empty 2.45 67.4 13.2 No No
8 empty 2.01 74.5 7.2 No No
9 empty 2.51 64.1 9.1 No No
10 empty 2.49 64.3 6.9 No No
5DHF_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 63.6 37 Yes No
2 bound 2.33 69.4 22.4 No No
3 empty 1.77 61.5 21.7 No No
4 empty 2.38 59.9 20.7 No No
5 empty 2.06 58.9 15.9 No No
6 empty 1.59 50 13 No No
7 empty 2.01 58.7 11.7 No No
8 empty 2.14 60.5 14.7 No No
9 empty 2.56 55.2 11 No No
10 empty 1.77 60.4 10.3 No No
3ZJY_F GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 72.5 31.9 Yes Yes
2 empty 2.29 70 15.7 No No
3 empty 2.1 59.7 16.5 No No
4 empty 2.31 61.4 18.4 No No
5 empty 2.42 77.4 10.6 No No
6 empty 2.12 67 12.5 No No
7 empty 2.43 63.4 9.8 No No
8 empty 1.93 62.2 7.6 No No
9 empty 2.39 62.6 10.2 No No
10 empty 1.75 77.9 7.5 No No
3GJ6_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 68 30.1 Yes No
2 empty 2.37 64.7 23.5 No No
3 empty 2.26 58.8 15.9 No No
4 empty 2.08 55.3 21.2 No No
5 bound 1.98 72.3 13 No No
6 empty 1.98 65.1 14.4 No No
7 empty 2.33 65.3 11.5 No No
8 empty 2.34 58.5 10.3 No No
9 empty 1.84 62.8 10.8 No No
10 empty 2.15 80.1 11.2 No No
3A6P_H GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 72.1 38.4 Yes No
2 empty 2.52 59.2 27.8 No No
3 empty 2.3 60.3 16.8 No No
4 empty 2.01 64.4 11.6 No No
5 empty 2.02 61.3 17.2 No No
6 empty 2.17 59 10.6 No No
7 empty 2.38 64.5 11.9 No No
8 empty 2.23 57.8 11.7 No No
9 empty 2.51 70.1 6.7 No No
10 empty 3.01 62.2 8.9 No No
5CIT_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 65.7 33.5 Yes No
2 empty 2.28 67.2 21.2 No No
3 empty 2.14 63.6 21.8 No No
4 bound 2.24 73.5 12.4 No No
5 empty 1.95 58 13.2 No No
6 empty 2.12 71.1 8.6 No No
7 empty 2.14 68.5 15 No No
8 empty 1.91 70.7 12.2 No No
9 empty 2.32 68 11 No No
10 empty 2.7 74.5 15.9 No No
4HAZ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 63.3 35.7 Yes No
2 empty 2.58 60.5 26.5 No No
3 empty 2.49 69.5 23.2 No No
4 empty 1.55 60 17.4 No No
5 empty 1.66 53 18.8 No No
6 empty 1.47 32.8 11.4 No No
7 empty 2.17 57.2 15.5 No No
8 empty 2.35 51.4 13.3 No No
9 empty 2.2 64 12 No No
10 empty 2.09 60.9 7.5 No No
4WVF_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 52.2 29.9 Yes No
2 bound 2.38 62.7 26.4 No No
3 empty 1.52 58.6 19.6 No No
4 empty 2.3 61 20 No No
5 bound 1.82 71.8 11.4 No No
6 empty 2.17 56 11.1 No No
7 empty 2 51.7 13.3 No No
8 empty 1.87 65.1 10.7 No No
9 bound 2.16 98.7 0 Yes No
10 empty 2.26 53.7 10.5 No No
3GJ5_C GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 69.8 24.4 Yes No
2 empty 2.33 65.4 20.2 No No
3 empty 2.3 58.1 19.9 No No
4 empty 2.08 64.4 17.7 No No
5 empty 2.14 66.1 12.2 No No
6 empty 2.26 69.1 16.8 No No
7 bound 2.02 69.9 14.7 No No
8 empty 2.28 64.7 19.1 No No
9 empty 2.32 60.6 12.5 No No
10 empty 2.11 75.2 12 No No
5CLQ_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 71.6 38.2 Yes No
2 empty 2.12 47.6 21 No No
3 empty 2.01 61.2 26.7 No No
4 bound 2.21 69.3 24.4 No No
5 empty 1.81 63.5 13.7 No No
6 empty 2.45 67.6 14.9 No No
7 empty 2.31 57.4 9.7 No No
8 empty 2.35 63 13.7 No No
9 empty 2.43 60.6 10.9 No No
10 empty 1.39 47 12.4 No No
3NBZ_F GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 69.5 40.5 Yes No
2 empty 2.52 61.1 25.9 No No
3 empty 1.91 62.5 15 No No
4 empty 2.41 63.4 17.3 No No
5 empty 2.06 56.9 17 No No
6 empty 2.28 66.4 11.3 No No
7 empty 2.44 60.8 9.8 No No
8 empty 2.42 61.8 10.8 No No
9 empty 2.39 64.9 10.5 No No
10 empty 1.79 63.9 8.4 No No
4HB3_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 65.7 47.3 Yes No
2 empty 2.46 60.1 25.1 No No
3 empty 1.56 59.1 18.1 No No
4 empty 1.55 33.6 10.7 No No
5 empty 2.14 59.5 15.7 No No
6 empty 1.8 70.4 10.7 No No
7 empty 1.85 57.4 12.1 No No
8 empty 1.72 60.5 11.1 No No
9 empty 2.59 60.1 11.6 No No
10 empty 1.68 50 12.8 No No
4C0Q_C GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 70.1 27.5 Yes No
2 bound 2.07 80.4 22.2 Yes Yes
3 empty 2.1 63.5 16.8 No No
4 empty 1.99 63.5 10.5 No No
5 empty 1.89 67.3 12.2 No No
6 empty 2.39 66 17.1 No No
7 empty 2.3 59.8 11.7 No No
8 empty 2.27 68.3 11.7 No No
9 empty 2.41 54 10.1 No No
10 empty 2.32 65.7 8.6 No No
3GJ8_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 64 25.3 Yes No
2 empty 2.35 65.6 32.6 No No
3 empty 2.23 67.1 15.9 No No
4 empty 2.41 61.6 25.6 No No
5 empty 2.3 65.8 20.9 No No
6 bound 2.11 75.4 11.1 No No
7 empty 2.36 64.8 22.8 No No
8 empty 2.42 60.9 11.6 No No
9 empty 2.14 74.6 11.7 No No
10 empty 2.06 63.5 10.1 No No
5BXQ_D GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 66 24.4 Yes No
2 empty 2.31 68.1 15.6 No No
3 empty 2.03 66.2 17.6 No No
4 empty 1.89 66.2 24.6 No No
5 bound 2.05 74.1 15.4 No No
6 empty 2.2 69.4 15.7 No No
7 empty 2.19 65.8 14.2 No No
8 empty 1.98 61.8 13.6 No No
9 empty 2.11 56.2 11.5 No No
10 empty 2.13 63.6 12.9 No No
6Q82_B GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 73.7 34.8 Yes Yes
2 empty 2.37 68.4 17.1 No No
3 empty 2.1 59.3 18.4 No No
4 empty 2.14 59.5 15.2 No No
5 empty 2.08 66.1 13.1 No No
6 empty 2.07 61.8 12.2 No No
7 empty 1.69 67.6 10.9 No No
8 empty 2.56 61.5 8.4 No No
9 empty 2.21 59.1 10.1 No No
10 empty 2.59 48 13.4 No No
5CJ2_E GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 63.6 32.3 Yes No
2 empty 2.15 61.6 29.5 No No
3 empty 2.32 70.1 18.7 No No
4 empty 2.15 63.7 18.8 No No
5 empty 2.2 65.1 20 No No
6 bound 2.14 71.4 14.1 No No
7 empty 2.39 69.1 17 No No
8 empty 2.31 59.9 10.7 No No
9 empty 2.08 68.7 10.4 No No
10 bound 1.64 72.9 10.7 No No
4HAW_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 51.9 30.1 Yes No
2 bound 2.28 63.2 30.1 No No
3 empty 1.52 57.2 18.7 No No
4 empty 2.4 58.1 22.8 No No
5 bound 1.76 76.9 12 No No
6 empty 2.04 53 13.4 No No
7 empty 2 52.6 12.2 No No
8 empty 2.15 56 11.1 No No
9 empty 2.63 53.6 11.3 No No
10 empty 1.71 55.5 10.3 No No
5UWO_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 63.4 38.6 Yes No
2 bound 2.34 69.3 29.8 No No
3 empty 2.44 60 22.7 No No
4 empty 1.57 60.1 18.4 No No
5 empty 1.62 31.6 13.8 No No
6 empty 2.07 61.6 14.9 No No
7 empty 2.33 54.7 12.4 No No
8 empty 1.62 53.2 12.8 No No
9 empty 1.72 58.7 10.3 No No
10 empty 2.48 55.1 9.7 No No
1K5G_J GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 53 26.5 Yes No
2 bound 2.07 72.5 30.5 No No
3 empty 1.51 60.6 17.4 No No
4 empty 2.36 65.6 26.1 No No
5 empty 2.45 58 25.1 No No
6 empty 1.77 49.1 14.2 No No
7 empty 2.19 61.3 11.4 No No
8 empty 1.27 61.6 10.3 No No
9 empty 1.69 60.7 12.5 No No
10 empty 1.77 55.4 12.6 No No
5DHA_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 55.8 29.2 Yes No
2 empty 1.59 61.4 18.2 No No
3 bound 2.3 58.4 23.4 No No
4 empty 2.4 60.6 21 No No
5 empty 1.59 42.2 14.6 No No
6 empty 2.01 47.5 11.5 No No
7 empty 2.36 55.8 10.3 No No
8 empty 2.35 54.3 12 No No
9 empty 2.3 50.7 14.5 No No
10 empty 2.25 65.4 11.8 No No
6CIT_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 62.4 38.2 Yes No
2 bound 2.46 69.3 29.8 No No
3 empty 2.55 59.2 26.1 No No
4 empty 1.76 59.4 21 No No
5 empty 1.87 46 16.5 No No
6 empty 2.08 58.3 15.4 No No
7 empty 2.12 52.3 13.5 No No
8 empty 2.55 58 11.6 No No
9 empty 1.55 53.9 12.9 No No
10 empty 1.75 57 10.2 No No
5YU6_B GTP-binding nuclear protein Ran Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 68.8 39.4 Yes Yes
2 empty 2.52 61.9 27 No No
3 empty 1.97 65.7 11.3 No No
4 empty 2.51 57.7 12.2 No No
5 empty 2.31 58.2 18.4 No No
6 empty 2.32 59.9 15.3 No No
7 empty 2.79 68.6 11.5 No No
8 empty 2.49 62.8 9.7 No No
9 empty 1.4 60.4 9.7 No No
10 empty 2.58 64.8 8.4 No No
3GJ3_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 64.2 38.4 Yes No
2 empty 2.32 60.2 14.9 No No
3 empty 2.2 69.4 27.9 No No
4 empty 2.14 64.1 15.4 No No
5 bound 1.84 71.3 17.6 No No
6 empty 2.36 57.9 17.8 No No
7 empty 2.17 68.9 14.8 No No
8 empty 1.96 59 15.8 No No
9 empty 1.99 66.9 12.9 No No
10 empty 2.38 62.3 10 No No
6A3C_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 51.8 28.5 Yes No
2 bound 2.25 62.7 23.4 No No
3 empty 2.4 58.7 21.6 No No
4 empty 1.58 57.9 18.7 No No
5 bound 1.77 73.5 10.8 No No
6 empty 2.27 53.5 10.4 No No
7 empty 1.93 54.1 11.2 No No
8 empty 2.68 53.1 11.6 No No
9 empty 1.73 56.9 10 No No
10 empty 1.53 39.4 10.6 No No
3NBY_F GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 75.9 33.6 Yes No
2 empty 2.49 60.2 26.9 No No
3 empty 1.73 66.4 18.4 No No
4 empty 2.36 59.6 15 No No
5 empty 2.06 58.7 15.7 No No
6 empty 2.47 66.3 12.2 No No
7 empty 1.69 65 15.6 No No
8 empty 1.76 71.9 7.3 No No
9 empty 2.61 66.2 9.9 No No
10 empty 2.18 61 10.4 No No
5CIQ_B GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 66.2 31.3 Yes No
2 empty 2.18 63.9 19.1 No No
3 bound 1.93 71.4 12.8 No No
4 empty 2.09 63.4 22.4 No No
5 empty 2.16 58.7 17.1 No No
6 empty 2.16 56.9 11.7 No No
7 empty 1.9 64.4 9.3 No No
8 empty 2.18 73 8.6 No No
9 empty 1.86 69.3 7 No No
10 empty 2.08 62.9 9.4 No No
6A3A_A GTP-binding nuclear protein Ran Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 50.1 29.2 Yes No
2 empty 2.36 57.6 20.9 No No
3 empty 1.54 59 19.8 No No
4 bound 2.28 62 23.9 No No
5 bound 1.72 71.4 11.3 No No
6 empty 2.18 57 12.8 No No
7 empty 1.97 50.8 12.1 No No
8 empty 2.46 53.1 12.2 No No
9 empty 1.96 56.9 11 No No
10 empty 1.69 58.4 8.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed22
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria16

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1I2M_C (61570) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.63Å No No
1I2M_A (61568) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.63Å No No
1IBR_A (32040) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.3Å Yes No
1IBR_C (32041) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.3Å Yes Yes
1K5D_J (68177) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.7Å No No
1K5D_G (68174) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.7Å No No
1K5D_D (68171) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.7Å No No
1K5D_A (68168) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.7Å Yes No
1K5G_J (68189) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 3.1Å Yes No
1K5G_G (68186) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 3.1Å Yes No
1K5G_D (68183) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 3.1Å Yes No
1K5G_A (68180) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 3.1Å Yes No
1QBK_C (32044) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 3Å No No
1RRP_A (32042) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.9Å Yes No
1RRP_C (32043) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.9Å Yes No
3GJ0_B (4001609) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.48Å Yes No
3GJ0_A (4223235) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.48Å Yes No
3GJX_C (3430708) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.5Å Yes No
3NBY_C (3630862) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3.42Å Yes Yes
3NBZ_C (3630870) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.8Å Yes No
3NC0_C (3630878) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.9Å Yes No
3NC1_C (3630885) GTP-binding nuclear protein Ran P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 3.35Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RAN is involved in 59 interactions in the network.


Druggability
Overall Druggability Percentile: 72.55
Druggability for Cancer Therapeutics: 92.51
Druggability for Other Therapeutics: 44.35
Cancer-Associated
Cancer-associated percentile : 95.54
Network Articulation Point
Is RAN critical for communication in the network?


Detailed Graph Legend:Help