Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB1A (P62820) - Overview - Molecular Target Synopsis

Protein


RAB1A, Ras-related protein Rab-1A
UniProt P62820

Also Known as RAB1A_HUMAN, RAB1A, RAB1

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. May interact with YIPF5 (By similarity). Interacts with C9orf72; the interaction mediates recruitment of RAB1A to the ATG1/ULK1 kinase complex (PubMed:27334615). Interacts with GDI1; this promotes dissociation from membranes (PubMed:23815289, PubMed:20176951).

4IRU
CRYSTAL STRUCTURE OF LEPB GAP CORE IN A TRANSITION STATE MIMETIC COMPLEX WITH RAB1A AND ALF3
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB1A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB1A is active in the following subcellular-locations: cytoplasm, cytosol, early endosome, endoplasmic reticulum, golgi apparatus, melanosome, membrane.
GO terms: RAB1A is active in the following subcellular-locations: cytosol, early endosome, endoplasmic reticulum membrane, extracellular exosome, Golgi apparatus, Golgi membrane, melanosome, transport vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB1A has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, UACC_257, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1792, OVMANA, SK23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For RAB1A there are:
11 structures (21 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB1A has been screened with compounds ( bioactivities). (see details)