Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTA2 (P62736) - Overview - Molecular Target Synopsis

Protein


ACTA2, Actin, aortic smooth muscle
UniProt P62736

Also Known as ACTA_HUMAN, ACTA2, ACTSA, ACTVS

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: ACTA2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTA2 is active in the following subcellular-locations: actin cytoskeleton, cell body, cytoplasm, cytosol, extracellular exosome, extracellular space, filopodium, lamellipodium, protein-containing complex, smooth muscle contractile fiber.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTA2 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, BT_549, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: M059K, Hs 940.T, BT-549

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, HSMM, BJ

(see details)

3D Structures


At greater than 90% identity similarity to ACTA2 there are:
65 structures (246 chains) solved
62 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTA2 has been screened with compounds ( bioactivities). (see details)