Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

bla,blaT-3,blaT-4,blaT-5,blaT-6 (P62593) - Overview - Molecular Target Synopsis

Protein


bla,blaT-3,blaT-4,blaT-5,blaT-6, Beta-lactamase TEM
Enzyme Classification 3.5.2.6
UniProt P62593

Also Known as BLAT_ECOLX, bla,blaT-3,blaT-4,blaT-5,blaT-6

TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.

6AYK
CRYSTAL STRUCTURE OF TEM1 BETA-LACTAMASE MUTANT I263A IN THE PRESENCE OF 1.2 MPA XENON
RCSB/PDB
Inspect Structure
See all 3D Structures for bla,blaT-3,blaT-4,blaT-5,blaT-6

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Drugs


bla,blaT-3,blaT-4,blaT-5,blaT-6 is targeted by Approved Drugs Tazobactam, Imipenem, Clavulanic Acid, Sulbactam. (see details)
Tazobactam
Imipenem
Clavulanic Acid
Sulbactam

Gene Copy Number Variation


In COSMIC - Cell Lines Project bla,blaT-3,blaT-4,blaT-5,blaT-6 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For bla,blaT-3,blaT-4,blaT-5,blaT-6 there are:
70 structures (128 chains) solved
23 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


bla,blaT-3,blaT-4,blaT-5,blaT-6 has been screened with 336 compounds (515 bioactivities), 101 compounds have bioactivities that show binding affinity of <= 500nM (123 bioactivities). (see details)