Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

nanA (P62575) - Overview - Molecular Target Synopsis

Protein


nanA, Sialidase A
Enzyme Classification 3.2.1.18
UniProt P62575

Also Known as NANA_STREE, nanA


5KKY
STRUCTURE OF STREPTOCOCCUS PNEUMONIA NANA BOUND WITH INHIBITOR 9N3NEU5AC2EN
RCSB/PDB
Inspect Structure
See all 3D Structures for nanA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: nanA is active in the following subcellular-locations: cell wall, secreted.
GO terms: nanA is active in the following subcellular-locations: cell wall, extracellular region, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project nanA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For nanA there are:
9 structures (19 chains) solved
7 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

nanA is solved in complex with the approved drug(s):

BGC/DEXTROSE (4C1X_A),
ZMR/ZANAMIVIR (2YA7_A, 2YA7_B, 2YA7_C, 2YA7_D).

(see details)
Molecular Target 3D Synopsis