Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LCN6 (P62502) - Overview - Molecular Target Synopsis

Protein


LCN6, Epididymal-specific lipocalin-6
UniProt P62502

Also Known as LCN6_HUMAN, LCN6, LCN5

May play a role in male fertility.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
163ENSG00000267206ENST00000341206ENSP00000339621P62502-1
78ENSG00000267206ENST00000476567ENSP00000468337

Sub-cellular localization


UniProt: LCN6 is active in the following subcellular-locations: secreted.
GO terms: LCN6 is active in the following subcellular-locations: extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LCN6 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SUP-B15, OCI-LY-19, NALM-6

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


LCN6 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)