Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Ligand Efficiency Plot
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ETF1 (P62495) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) RPL4 (P36578), RPL12 (P30050), RPL17 (P18621) HUMAN 5A8L_Q 100 0 3.8Å - 2015-12-02
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) - HUMAN 1DT9_A 100 0 2.7Å - 2000-02-02
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) SUP45 (P12385) SUP35 (P05453) BAKER'S YEAST 4CRN_X 68.22 0 9.1Å - 2014-07-23
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) sup45 (P79063) sup35 (O74718) FISSION YEAST 3E20_H 65.21 0 3.5Å - 2009-05-19
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) GSPT1 (P15170) HUMAN 3E1Y_C 100 0 3.8Å - 2009-05-19
eRF1 domain 1 (1%), eRF1 domain 2 (99%) (view alignment) ETF1 (P62495) - HUMAN 2HST_A 100 0 - 2007-06-26
eRF1 domain 1 (100%) (view alignment) ETF1 (P62495) - HUMAN 2LGT_A 100 0 - 2012-03-14
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) GSPT1 (P15170) HUMAN 3J5Y_A 100 0 9.7Å - 2013-12-25
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) sup45 (P79063) sup35 (O74718) FISSION YEAST 3E20_K 65.21 0 3.5Å - 2009-05-19
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) - HUMAN 4D5N_A 100 0 9Å - 2015-02-04
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) Etf1 (Q8BWY3) gag-pol (P03355) MOUSE 5DMQ_B 100 0 4Å - 2016-07-06
eRF1 domain 2 (2%), eRF1 domain 3 (100%) (view alignment) Etf1 (Q8BWY3) gag-pol (P03355) MOUSE 5DMR_B 100 5.0E-93 2.8Å - 2016-07-06
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) GSPT1 (P15170) HUMAN 3E1Y_D 100 0 3.8Å - 2009-05-19
eRF1 domain 1 (100%) (view alignment) ETF1 (P62495) - HUMAN 2MQ9_A 100 0 - 2015-07-01
eRF1 domain 1 (100%) (view alignment) ETF1 (P62495) - HUMAN 2LLX_A 100 0 - 2012-05-30
eRF1 domain 1 (100%) (view alignment) ETF1 (P62495) - HUMAN 2MQ6_A 100 0 - 2015-06-17
eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) SUP45 (P12385) RLI1 (Q03195) BAKER'S YEAST 4CRM_X 67.14 3.0E-112 8.75Å - 2014-07-23
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) sup45 (P79063) sup35 (O74718) FISSION YEAST 3E20_C 65.21 0 3.5Å - 2009-05-19
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) sup45 (P79063) sup35 (O74718) FISSION YEAST 3E20_B 65.21 0 3.5Å - 2009-05-19
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) GSPT1 (P15170) HUMAN 3E1Y_A 100 0 3.8Å ATP 2009-05-19
eRF1 domain 2 (2%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) - HUMAN 2KTV_A 100 0 - 2010-06-09
eRF1 domain 2 (2%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) - HUMAN 2KTU_A 100 0 - 2010-06-09
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) (G1TFE8), (G1TDB3), (G1TM82), (G1U7M4), (G1SWM1), (G1SIZ2), (G1TG89), (G1TS40), (G1T168), (G1TZ76), (G1SFR8), (G1TU13), GSPT1 (P15170), (G1TWL4), (G1SZ47), (G1TFM5), (G1U0Q2), (G1SK22), (G1SJB4), (G1T1F0), (G1TN62), (G1TJW1), (G1SGX4), (G1TK17), (G1SS70), (G1SVB0), (G1TPG3), (G1SP51), (G1TM55), (G1TRM4), (G1TIB4), (B7NZS8), (G1T8A2), (G1TNM3) HUMAN 4D61_h 100 0 9Å - 2015-03-04
eRF1 domain 1 (100%), eRF1 domain 2 (100%), eRF1 domain 3 (100%) (view alignment) ETF1 (P62495) GSPT1 (P15170) HUMAN 3E1Y_B 100 0 3.8Å ATP 2009-05-19