Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ETF1 (P62495) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 03/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 03/09/2019)


Chains assessed18
Chains with at least one site assessed as druggable using the strict criteria5
Chains with at least one site assessed as druggable using the relaxed criteria15


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5A8L_Q Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 65.8 57.4 Yes No
2 empty 2.1 67.4 39.2 No No
3 empty 2.37 58.4 28.5 No No
4 empty 2.06 59.4 24.8 No No
5 empty 2.68 65.8 21.9 No No
6 empty 2 65.6 18.5 No No
7 empty 1.96 65.9 16.2 No No
8 empty 1.97 74 13.9 No No
9 empty 2.3 69.1 15.1 No No
10 empty 1.99 68.4 14.3 No No
1DT9_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 64.3 65.3 Yes No
2 empty 2.37 71.3 23.1 No No
3 empty 2.25 69.5 22.2 No No
4 empty 2.1 61.5 13.5 No No
5 empty 2.62 58.6 15.4 No No
6 empty 2.35 58.2 13.8 No No
7 empty 2.1 68.6 11.5 No No
8 empty 1.92 57.9 11.7 No No
9 empty 2.39 57.3 9.9 No No
10 empty 1.92 72.5 9.1 No No
3E1Y_C Eukaryotic peptide chain release factor subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 68.7 47.6 Yes Yes
2 empty 2.22 63.2 23.1 No No
3 empty 2.23 56.3 32.8 No No
4 empty 2.45 61.7 22.9 No No
5 empty 2 62.9 15.2 No No
6 empty 2.42 65.3 19.8 No No
7 empty 2.12 63.3 10.8 No No
8 empty 2.2 55.4 15.2 No No
9 empty 2.59 62.8 9.4 No No
10 empty 2.28 60.6 12.3 No No
2HST_A Eukaryotic peptide chain release factor subunit 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.3 23.8 No No
2 empty 2.09 67 19.6 No No
3 empty 1.77 68.2 18 No No
4 empty 1.97 53.7 16.8 No No
5 empty 2.8 63.1 11.9 No No
6 empty 1.96 68 11.6 No No
7 empty 2.16 62.7 7.3 No No
8 empty 2.53 64.9 10.7 No No
9 empty 2.44 68.1 10.3 No No
10 empty 2.55 60.6 7.1 No No
2LGT_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 61.9 31.9 Yes No
2 empty 2.08 65.7 15.4 No No
3 empty 1.89 69.9 14.5 No No
4 empty 2.06 64.1 18.8 No No
5 empty 2.39 66 12.8 No No
6 empty 1.97 56.9 10.5 No No
7 empty 2.56 67.2 12.9 No No
8 empty 2.49 64.1 11.9 No No
9 empty 2.43 64.9 10.5 No No
10 empty 3.05 68 8 No No
3J5Y_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 63.4 55.8 Yes No
2 empty 2.08 64.6 29.7 No No
3 empty 2.22 63.8 31.8 No No
4 empty 2.26 68.7 27.9 No No
5 empty 2.09 58.5 27.6 No No
6 empty 2.3 61.3 17.5 No No
7 empty 2.84 62.9 21.3 No No
8 empty 2.1 60.7 22.2 No No
9 empty 1.79 64.7 13.7 No No
10 empty 2.24 57.2 17.1 No No
4D5N_A Eukaryotic peptide chain release factor subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 68.2 52.2 Yes Yes
2 empty 2.15 67.9 34.7 No No
3 empty 1.96 69.1 26.7 No No
4 empty 2.09 69.3 24.8 No No
5 empty 1.99 63 26.9 No No
6 empty 1.94 63.9 24.5 No No
7 empty 2.14 62.8 23.3 No No
8 empty 1.58 82.3 18.3 No No
9 empty 2.4 64.4 16.5 No No
10 empty 1.89 74.2 14.6 No No
5DMQ_B Eukaryotic peptide chain release factor subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 66.4 60.1 Yes Yes
2 empty 2.23 63.7 35 No No
3 empty 1.97 64.1 18.1 No No
4 empty 2 69.9 19.3 No No
5 empty 2.58 64.7 17.5 No No
6 empty 2.06 65.5 16.5 No No
7 empty 2.5 63.7 15.9 No No
8 empty 2.08 61.4 11.1 No No
9 empty 2.23 62 16.4 No No
10 empty 1.56 68.4 11.2 No No
5DMR_B Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 60.7 24.1 Yes No
2 empty 2.11 57.9 15.8 No No
3 empty 2.43 63.2 14 No No
4 empty 1.64 58.2 13.3 No No
5 empty 2.41 62.9 11.9 No No
6 empty 2.25 63.3 14 No No
7 empty 2.61 73 7.3 No No
8 empty 2.08 60 9.5 No No
9 empty 1.59 60.3 7.5 No No
10 empty 2.7 66.1 7.2 No No
3E1Y_D Eukaryotic peptide chain release factor subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 69 45.6 Yes Yes
2 empty 2.06 65.7 33.7 No No
3 empty 2.42 57.8 34.5 No No
4 empty 2.13 62.9 25 No No
5 empty 2.43 61.7 23 No No
6 empty 2.13 63.3 16.9 No No
7 empty 2.54 66.9 14.8 No No
8 empty 2.13 60.9 10.4 No No
9 empty 2.64 63.9 10.3 No No
10 empty 2.29 61.9 9.8 No No
2MQ9_A Eukaryotic peptide chain release factor subunit 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 59.3 22.4 No No
2 empty 1.74 65.3 22.9 No No
3 empty 2.3 68.2 17.5 No No
4 empty 2.11 58.1 20.8 No No
5 empty 2.6 51.5 15.7 No No
6 empty 2.13 71.3 14.6 No No
7 empty 2.07 53.2 13.1 No No
8 empty 2.18 77.7 11.3 No No
9 empty 2.25 73.5 11 No No
10 empty 2.23 69.2 10.6 No No
2LLX_A Eukaryotic peptide chain release factor subunit 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 58.1 22.7 No No
2 empty 2.17 68.8 19.1 No No
3 empty 2.3 70.1 20 No No
4 empty 2.26 56.6 11.2 No No
5 empty 2.04 58.6 13.8 No No
6 empty 2.4 55 14.2 No No
7 empty 2.52 62 11.9 No No
8 empty 2.42 59.9 18.9 No No
9 empty 1.95 62.3 11.7 No No
10 empty 2.41 64.2 6.8 No No
2MQ6_A Eukaryotic peptide chain release factor subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 67.1 25 Yes Yes
2 empty 2.06 63.6 22.3 No No
3 empty 2.07 67.6 26.8 No No
4 empty 1.54 60.4 21.5 No No
5 empty 1.94 65.7 11.1 No No
6 empty 1.78 52.5 14.1 No No
7 empty 1.87 57.3 13.5 No No
8 empty 2.32 71.2 11.3 No No
9 empty 1.89 74 10.1 No No
10 empty 2.33 53.7 8.9 No No
3E1Y_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.4 60.3 Yes No
2 empty 2.31 62 27.3 No No
3 bound 2.37 57.1 21 No No
4 empty 2.52 61.2 16.5 No No
5 empty 2.38 60.2 15.1 No No
6 empty 2.56 69.5 16.4 No No
7 empty 1.94 62.4 13.3 No No
8 empty 2.14 57.9 13.7 No No
9 empty 2.31 65.6 13.5 No No
10 empty 2.43 67.2 8.5 No No
2KTV_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 65.6 39.8 Yes No
2 empty 2.21 64.6 24.4 No No
3 empty 2.26 64.1 16.1 No No
4 empty 2.54 60.6 14.8 No No
5 empty 1.88 57.7 18.2 No No
6 empty 2.8 57.6 11 No No
7 empty 2.03 56.7 12.3 No No
8 empty 2.34 59.8 10.8 No No
9 empty 2.85 56.8 13.2 No No
10 empty 2.24 49.5 11.5 No No
2KTU_A Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.8 45.4 Yes No
2 empty 2.4 63 26.2 No No
3 empty 2.56 62.1 17.7 No No
4 empty 2.63 60 9.5 No No
5 empty 2.11 64 8.5 No No
6 empty 2.06 71 9.1 No No
7 empty 2.34 63.6 10.9 No No
8 empty 1.88 69.8 9.1 No No
9 empty 2.43 68 12.4 No No
10 empty 2.6 81.3 6.9 No No
4D61_h Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 65.3 63.9 Yes No
2 empty 2.14 60.8 45.2 No No
3 empty 1.93 77.1 24.1 No No
4 empty 2.18 68.2 29.3 No No
5 empty 1.77 51.7 22.4 No No
6 empty 2.46 62.1 34 No No
7 empty 2.65 65.1 21.5 No No
8 empty 2.07 60.4 14.9 No No
9 empty 2.08 67.6 16.9 No No
10 empty 2.05 64.3 14.1 No No
3E1Y_B Eukaryotic peptide chain release factor subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 64.9 60.4 Yes No
2 empty 2.17 62.9 25.1 No No
3 bound 2.36 57.5 21.6 No No
4 empty 2.18 64.5 17.1 No No
5 empty 2.5 60.3 19.3 No No
6 empty 1.96 61.3 17.9 No No
7 empty 2.4 62.8 18.8 No No
8 empty 2.4 62.8 13.8 No No
9 empty 2.18 54.6 14.3 No No
10 empty 2.35 66.2 11.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1DT9_A (33738) Eukaryotic peptide chain release factor subunit 1 Ribonuclease H-like motif, Translational machinery components, ERF1/Dom34 middle domain-like 2.7Å No No
1DT9_A (39815) Eukaryotic peptide chain release factor subunit 1 Bacillus chorismate mutase-like, L30e-like, ERF1/Dom34 C-terminal domain-like 2.7Å Yes No
1DT9_A (40257) Eukaryotic peptide chain release factor subunit 1 N-terminal domain of eukaryotic peptide chain release factor subunit 1 ERF1, N-terminal domain of eukaryotic peptide chain release factor subunit 1 ERF1, N-terminal domain of eukaryotic peptide chain release factor subunit 1 ERF1 2.7Å Yes No
2HST_A (147395) Eukaryotic peptide chain release factor subunit 1 Ribonuclease H-like motif, Translational machinery components, ERF1/Dom34 middle domain-like No No
2KTU_A (3150224) Eukaryotic peptide chain release factor subunit 1 Bacillus chorismate mutase-like, L30e-like, ERF1/Dom34 C-terminal domain-like Yes No
2KTV_A (3150226) Eukaryotic peptide chain release factor subunit 1 Bacillus chorismate mutase-like, L30e-like, ERF1/Dom34 C-terminal domain-like Yes No
3E1Y_A (3370636) Eukaryotic peptide chain release factor subunit 1 Bacillus chorismate mutase-like, L30e-like, ERF1/Dom34 C-terminal domain-like 3.8Å Yes No
3E1Y_A (3370634) Eukaryotic peptide chain release factor subunit 1 N-terminal domain of eukaryotic peptide chain release factor subunit 1 ERF1, N-terminal domain of eukaryotic peptide chain release factor subunit 1 ERF1, UNMATCHED 3.8Å Yes No
3E1Y_A (3370635) Eukaryotic peptide chain release factor subunit 1 Ribonuclease H-like motif, Translational machinery components, ERF1/Dom34 middle domain-like 3.8Å No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ETF1 is involved in 10 interactions in the network.


Druggability
Overall Druggability Percentile: 82.65
Druggability for Cancer Therapeutics: 73.93
Druggability for Other Therapeutics: 85.84
Cancer-Associated
Cancer-associated percentile : 71.48
Network Articulation Point
Is ETF1 critical for communication in the network?


Detailed Graph Legend:Help