Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RRAS2 (P62070) - Overview - Molecular Target Synopsis

Protein


RRAS2, Ras-related protein R-Ras2
UniProt P62070

Also Known as RRAS2_HUMAN, RRAS2, TC21

It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

2ERY
THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2 (RRAS2) IN THE GDP BOUND STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for RRAS2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RRAS2 is active in the following subcellular-locations: cell membrane.
GO terms: RRAS2 is active in the following subcellular-locations: endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRAS2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, IGROV1, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2452, Hs 746T, NCI-H2052

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, IMR-90

(see details)

3D Structures


For RRAS2 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RRAS2 has been screened with compounds ( bioactivities). (see details)