Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PKIA (P61926) - Overview - Molecular Target Synopsis

Protein


PKIA, cAMP-dependent protein kinase inhibitor alpha
UniProt P61926

Also Known as IPKA_RABIT, PKIA, PRKACN1

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

5UZK
18 RESIDUE FRAGMENT OF
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF PKA BOUND TO AN PYRROLO PYRIDINE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for PKIA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Gene Copy Number Variation


In COSMIC - Cell Lines Project PKIA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For PKIA there are:
22 structures (23 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis