Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PKIA (P61925) - Overview - Molecular Target Synopsis

Protein


PKIA, cAMP-dependent protein kinase inhibitor alpha
UniProt P61925

Also Known as IPKA_HUMAN, PKIA, PRKACN1

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

2VO0
20 RESIDUE FRAGMENT OF
CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA
IN THE STRUCTURE OF
STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH C-(4-(4- CHLOROPHENYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDIN- 4-YL)METHYLAMINE
RCSB/PDB
Inspect Structure
See all 3D Structures for PKIA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: PKIA is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PKIA has gain in 16 cell-lines, loss in 2 cell-lines and no signal in 987 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, LOXIMVI, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, SK-N-AS, MDA-MB-361

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, MCF-7, HSMM

(see details)

RNA Interference


PKIA was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HUO9, NOS1. (see details)

3D Structures


For PKIA there are:
103 structures (109 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis