Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

mdh (P61889) - Overview - Molecular Target Synopsis

Protein


mdh, Malate dehydrogenase
Enzyme Classification 1.1.1.37
UniProt P61889

Also Known as MDH_ECOLI, mdh

Catalyzes the reversible oxidation of malate to oxaloacetate. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: mdh is active in the following subcellular-locations: cytoplasm, cytosol, extrinsic component of membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project mdh has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For mdh there are:
8 structures (24 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


mdh has been screened with compounds ( bioactivities). (see details)