Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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sirC (P61818) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3DFZ_B Precorrin-2 dehydrogenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 67.6 35.2 Yes Yes
2 empty 2.16 61.6 27.8 No No
3 empty 2.61 61.7 23.9 No No
4 empty 2.47 65.1 16.3 No No
5 empty 2.19 73 13.9 No No
6 empty 2.41 72.5 10.5 No No
7 empty 2.41 67.8 11.4 No No
8 empty 2.2 70.5 8.6 No No
9 bound 2.7 55.2 9.4 No No
10 empty 2.75 63.7 12 No No
3DFZ_A Precorrin-2 dehydrogenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 68.3 32.4 Yes Yes
2 bound 2.48 68.2 34.6 No No
3 empty 1.81 58.2 24.9 No No
4 bound 2.34 57.5 18.3 No No
5 empty 1.81 58.7 12.6 No No
6 empty 2.59 65 15.5 No No
7 empty 2.46 57.2 16.3 No No
8 empty 2.61 65.4 9.8 No No
9 empty 2.26 54.5 12 No No
10 empty 2.29 64.5 9.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria3

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3DFZ_A (3360263) Precorrin-2 dehydrogenase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, UNMATCHED 2.3Å Yes No
3DFZ_A (3360265) Precorrin-2 dehydrogenase PFAM, PFAM, PFAM MR_MLE 2.3Å Yes No
3DFZ_A (4238464) Precorrin-2 dehydrogenase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Siroheme synthase N-terminal domain-like 2.3Å Yes No
3DFZ_B (4238464) Precorrin-2 dehydrogenase NAD(P)-binding Rossmann-fold domains, NAD(P)-binding Rossmann-fold domains, Siroheme synthase N-terminal domain-like 2.3Å Yes No
3DFZ_B (3360266) Precorrin-2 dehydrogenase UNMATCHED, UNMATCHED, UNMATCHED 3DFZ 2.3Å No Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score