Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Stxbp1 (P61765) - Overview - Molecular Target Synopsis

Protein


Stxbp1, Syntaxin-binding protein 1
UniProt P61765

Also Known as STXB1_RAT, Stxbp1, Unc18a

May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Binds SYTL4 and STX1A (PubMed:10746715). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation.

4JEU
CRYSTAL STRUCTURE OF MUNC18A AND SYNTAXIN1 WITH NATIVE N-TERMINUS COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for Stxbp1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
603ENSG00000136854ENST00000373302ENSP00000362399P61765-2, O08599-2, P61764-2

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Stxbp1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Stxbp1 there are:
4 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis