Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAA20 (P61599) - Overview - Molecular Target Synopsis

Protein


NAA20, N-alpha-acetyltransferase 20
Enzyme Classification 2.3.1.254
UniProt P61599

Also Known as NAA20_HUMAN, NAA20, NAT5

Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration. Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAA20 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NAA20 is active in the following subcellular-locations: cytoplasm, cytosol, intracellular, NatB complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA20 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BICR 22, G121, PE/CA-PJ15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to NAA20 there are:
2 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis