Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RND3 (P61587) - Overview - Molecular Target Synopsis

Protein


RND3, Rho-related GTP-binding protein RhoE
UniProt P61587

Also Known as RND3_HUMAN, RND3, ARHE, RHO8, RHOE

Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Binds ROCK1 (By similarity). Interacts with UBXD5.

2V55
MECHANISM OF MULTI-SITE PHOSPHORYLATION FROM A ROCK-I:RHOE COMPLEX STRUCTURE
RCSB/PDB
Inspect Structure
See all 3D Structures for RND3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
115ENSG00000115963ENST00000409557ENSP00000386576

Sub-cellular localization


UniProt: RND3 is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: RND3 is active in the following subcellular-locations: cell cortex, cell division site, cytoplasm, focal adhesion, Golgi membrane, intracellular membrane-bounded organelle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RND3 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, NCI_H226, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 895.T, Hs 255.T, HCC2885

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

3D Structures


For RND3 there are:
3 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RND3 has been screened with compounds ( bioactivities). (see details)