Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Isl1 (P61372) - Overview - Molecular Target Synopsis

Protein


Isl1, Insulin gene enhancer protein ISL-1
UniProt P61372

Also Known as ISL1_MOUSE, Isl1

DNA-binding transcriptional activator (PubMed:14664703, PubMed:24643061, PubMed:25775587, PubMed:22343712). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes (PubMed:24643061, PubMed:25775587). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587). Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587). Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (PubMed:14667410). At neuronal promoters, displaces LDB1 from LHX3 LIM domain to form a ternary complex in which ISL1 contacts both LHX3 and LDB1 (PubMed:18583962). Interacts (via C-terminus) with POU4F2 (via C-terminus) isoform 1 (PubMed:24643061). Interacts with POU3F2 (PubMed:24643061). Interacts with POU4F3 (PubMed:24643061). Interacts (via N-terminal domain) with MLIP; the interaction represses ISL1 transactivator activity (PubMed:22343712).

4JCJ
CRYSTAL STRUCTURE OF ISL1 LIM DOMAINS WITH LDB1 LIM-INTERACTION DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for Isl1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
326ENSG00000016082ENST00000511384ENSP00000422676P61372-2, P61374-2

Sub-cellular localization


UniProt: Isl1 is active in the following subcellular-locations: nucleus.
GO terms: Isl1 is active in the following subcellular-locations: nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Isl1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Isl1 there are:
2 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Isl1 has been screened with compounds ( bioactivities). (see details)