Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAP2B (P61225) - Overview - Molecular Target Synopsis


RAP2B, Ras-related protein Rap-2b
UniProt P61225

Also Known as RAP2B_HUMAN, RAP2B

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. Interacts with PLCE1. Interacts with SGSM1, SGSM2 and SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAP2B is active in the following subcellular-locations: recycling endosome membrane.
GO terms: RAP2B is active in the following subcellular-locations: bicellular tight junction, cell-cell contact zone, cytosol, extracellular exosome, membrane, membrane raft, plasma membrane, recycling endosome membrane, specific granule membrane, tertiary granule membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAP2B has gain in 7 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, RPMI_8226, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, HCC4011, BICR 22

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, NHLF

(see details)

3D Structures

At greater than 90% identity similarity to RAP2B there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAP2B has been screened with compounds ( bioactivities). (see details)