Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAP1B (P61224) - Overview - Molecular Target Synopsis


RAP1B, Ras-related protein Rap-1b
UniProt P61224

Also Known as RAP1B_HUMAN, RAP1B

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. Heterodimer with RAP1GAP. Interacts with EPAC2, SGSM1, SGSM2 and SGSM3. Interacts with KRIT1.

Inspect Structure
See all 3D Structures for RAP1B

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAP1B is active in the following subcellular-locations: cell junction, cell membrane, cytoplasm, cytosol.
GO terms: RAP1B is active in the following subcellular-locations: azurophil granule membrane, cell-cell junction, cytosol, extracellular exosome, intracellular, lipid droplet, membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAP1B has gain in 7 cell-lines, loss in 2 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H226, ACHN, IGROV1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, QGP-1, RERF-LC-MS

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, AG445

(see details)

3D Structures

For RAP1B there are:
14 structures (25 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAP1B has been screened with compounds ( bioactivities). (see details)