Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCE1 (P61221) - Overview - Molecular Target Synopsis

Protein


ABCE1, ATP-binding cassette sub-family E member 1
UniProt P61221

Also Known as ABCE1_HUMAN, ABCE1, RLI, RNASEL1, RNASELI, RNS4I

Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCE1 is active in the following subcellular-locations: cytoplasm, mitochondrion.
GO terms: ABCE1 is active in the following subcellular-locations: cytoplasm, cytosol, membrane, mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCE1 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HL_60, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEY, OVCAR-8, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCE1 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis