ABCE1 (P61221) - Overview - Molecular Target Synopsis
ABCE1, ATP-binding cassette sub-family E member 1
Also Known as ABCE1_HUMAN, ABCE1, RLI, RNASEL1, RNASELI, RNS4I
Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Probably heterodimerizes with RNASEL; this interaction inhibits the RNASEL.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: ABCE1 is active in the following subcellular-locations: cytoplasm, mitochondrion.
GO terms: ABCE1 is active in the following subcellular-locations: cytoplasm, cytosol, membrane, mitochondrial matrix, mitochondrion.