Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARF3 (P61204) - Overview - Molecular Target Synopsis

Protein


ARF3, ADP-ribosylation factor 3
UniProt P61204

Also Known as ARF3_HUMAN, ARF3

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Interacts with PRKCABP. Interacts with PI4KB and NCS1/FREQ at the Golgi complex.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARF3 is active in the following subcellular-locations: cytoplasm, golgi apparatus, perinuclear region.
GO terms: ARF3 is active in the following subcellular-locations: cytoplasm, extracellular exosome, Golgi apparatus, Golgi membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARF3 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, LOXIMVI, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ChaGo-K-1, SK-N-FI, LCLC-97TM1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


At greater than 90% identity similarity to ARF3 there are:
20 structures (44 chains) solved
19 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARF3 has been screened with compounds ( bioactivities). (see details)