Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTR1A (P61163) - Overview - Molecular Target Synopsis

Protein


ACTR1A, Alpha-centractin
UniProt P61163

Also Known as ACTZ_HUMAN, ACTR1A, CTRN1

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome. Interacts with BCCIP (isoform 2/alpha).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACTR1A is active in the following subcellular-locations: cell cortex, centrosome, cytoplasm, cytoskeleton, microtubule organizing center.
GO terms: ACTR1A is active in the following subcellular-locations: cell cortex region, centriole, centrosome, COPI-coated vesicle, cytoplasm, cytosol, dynactin complex, extracellular exosome, manchette, microtubule associated complex, microtubule cytoskeleton.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTR1A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, HOP_62, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, SJCRH30, SNU-423

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ACTR1A there are:
4 structures (27 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTR1A has been screened with compounds ( bioactivities). (see details)