ACTR2 (P61160) - Overview - Molecular Target Synopsis
ACTR2, Actin-related protein 2
Also Known as ARP2_HUMAN, ACTR2, ARP2
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|394||ENSG00000138071||ENST00000260641||ENSP00000260641||P61161-1, A7MB62-1, P61160-1|
UniProt: ACTR2 is active in the following subcellular-locations: cell projection, cytoplasm, cytoskeleton, nucleus.
GO terms: ACTR2 is active in the following subcellular-locations: actin cap, actin cytoskeleton, Arp2/3 protein complex, azurophil granule lumen, cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, focal adhesion, invadopodium, lamellipodium, membrane, nucleus, podosome core, postsynaptic density, site of double-strand break.