Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTR2 (P61160) - Overview - Molecular Target Synopsis

Protein


ACTR2, Actin-related protein 2
UniProt P61160

Also Known as ARP2_HUMAN, ACTR2, ARP2

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACTR2 is active in the following subcellular-locations: cell projection, cytoplasm, cytoskeleton, nucleus.
GO terms: ACTR2 is active in the following subcellular-locations: actin cap, actin cytoskeleton, Arp2/3 protein complex, azurophil granule lumen, cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, focal adhesion, invadopodium, lamellipodium, membrane, nucleus, podosome core, postsynaptic density, site of double-strand break.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTR2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, HL_60, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, Hs 578T, MDA-MB-157

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


For ACTR2 there are:
19 structures (21 chains) solved
12 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTR2 has been screened with 17 compounds (17 bioactivities). (see details)