Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ACTR3 (P61158) - Overview - Molecular Target Synopsis


ACTR3, Actin-related protein 3
UniProt P61158

Also Known as ARP3_HUMAN, ACTR3, ARP3

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9000076, PubMed:9230079, PubMed:11741539). Interacts with WHDC1 (PubMed:18614018). Interacts weakly with MEFV (PubMed:19109554).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ACTR3 is active in the following subcellular-locations: cell projection, cytoplasm, cytoskeleton, nucleus.
GO terms: ACTR3 is active in the following subcellular-locations: actin cytoskeleton, Arp2/3 protein complex, brush border, cell-cell junction, cytoplasm, cytosol, extracellular exosome, focal adhesion, lamellipodium, membrane, nucleus, site of double-strand break.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ACTR3 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: HS578T, RXF_393, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVCAR-8, Hs 578T, HCC366

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures

For ACTR3 there are:
20 structures (22 chains) solved
13 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ACTR3 has been screened with compounds ( bioactivities). (see details)