ACTR3 (P61158) - Overview - Molecular Target Synopsis
ACTR3, Actin-related protein 3
Also Known as ARP3_HUMAN, ACTR3, ARP3
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9000076, PubMed:9230079, PubMed:11741539). Interacts with WHDC1 (PubMed:18614018). Interacts weakly with MEFV (PubMed:19109554).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|418||ENSG00000115091||ENST00000263238||ENSP00000263238||P61158-1, Q5R8R1-1, P61157-1|
UniProt: ACTR3 is active in the following subcellular-locations: cell projection, cytoplasm, cytoskeleton, nucleus.
GO terms: ACTR3 is active in the following subcellular-locations: actin cytoskeleton, Arp2/3 protein complex, brush border, cell-cell junction, cytoplasm, cytosol, extracellular exosome, focal adhesion, lamellipodium, membrane, nucleus, site of double-strand break.