Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB14 (P61106) - Overview - Molecular Target Synopsis

Protein


RAB14, Ras-related protein Rab-14
UniProt P61106

Also Known as RAB14_HUMAN, RAB14

Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Interacts with KIF16B (By similarity). Interacts with ZFYVE20.

4D0G
STRUCTURE OF RAB14 IN COMPLEX WITH RAB-COUPLING PROTEIN (RCP)
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB14

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
215ENSG00000119396ENST00000373840ENSP00000362946Q5R8Z8-1, Q5ZKU5-1, Q91V41-1, P61106-1
188ENSG00000119396ENST00000451303ENSP00000400107

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB14 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, COLO205, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVKATE, HEY, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, MCF-7

(see details)

3D Structures


For RAB14 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB14 has been screened with compounds ( bioactivities). (see details)