Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB10 (P61026) - Overview - Molecular Target Synopsis

Protein


RAB10, Ras-related protein Rab-10
UniProt P61026

Also Known as RAB10_HUMAN, RAB10

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane while in epithelial cells, it regulates transport from the Golgi to the basolateral membrane. Moreover, may play a role in the basolateral recycling pathway and in phagosome maturation. According to PubMed:23263280, may play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Interacts with GDI1 and maybe with GDI2; negatively regulates RAB10 association with membranes and activation (PubMed:19570034). Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity). Interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 and EHBP1L1; at least in case of MICAL1 two molecules of RAB10 can bind to one molecule of MICAL1 (PubMed:27552051). Interacts with TBC1D13 (By similarity). Interacts with SEC16A.

5LPN
STRUCTURE OF HUMAN RAB10 IN COMPLEX WITH THE BMERB DOMAIN OF MICAL-1
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB10

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
200ENSG00000084733ENST00000264710ENSP00000264710P61027-1, P61026-1, Q5R5U1-1

Sub-cellular localization


UniProt: RAB10 is active in the following subcellular-locations: cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, endoplasmic reticulum membrane, endosome membrane, golgi apparatus, golgi apparatus membrane, perinuclear region, phagosome membrane, recycling endosome membrane, trans-golgi network membrane.
GO terms: RAB10 is active in the following subcellular-locations: cell-cell adherens junction, cilium, cytoplasmic vesicle membrane, cytosol, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, exocytic vesicle, extracellular exosome, focal adhesion, Golgi apparatus, Golgi membrane, insulin-responsive compartment, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, secretory granule membrane, synaptic vesicle, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB10 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, HCC_2998, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2302, NCI-H1623, HCC-15

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, HSMM

(see details)

3D Structures


For RAB10 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB10 has been screened with compounds ( bioactivities). (see details)