Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB5B (P61020) - Overview - Molecular Target Synopsis

Protein


RAB5B, Ras-related protein Rab-5B
UniProt P61020

Also Known as RAB5B_HUMAN, RAB5B

Protein transport. Probably involved in vesicular traffic. Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.

2HEI
CRYSTAL STRUCTURE OF HUMAN RAB5B IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB5B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB5B is active in the following subcellular-locations: cell membrane, early endosome membrane, melanosome.
GO terms: RAB5B is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, early endosome, early endosome membrane, endocytic vesicle, endosome, extracellular exosome, intracellular, intracellular membrane-bounded organelle, melanosome, membrane, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB5B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MALME_3M, T47D, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DEOC-1, NCI-H209, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, BJ

(see details)

3D Structures


For RAB5B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB5B has been screened with compounds ( bioactivities). (see details)