Molecular Target Synopsis
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RAB2A (P61019) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria3


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1Z0A_C Ras-related protein Rab-2A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.02 73.8 24.1 Yes No
2 empty 2.21 64.9 29.8 No No
3 empty 2.23 63.1 22 No No
4 empty 2.38 60.6 16.1 No No
5 empty 2.47 61 19 No No
6 empty 2.28 66.3 11.1 No No
7 empty 2.79 63.2 10.7 No No
8 empty 2.28 63.3 11.5 No No
9 empty 2.49 77.6 7.5 No No
10 empty 1.51 53.1 8.8 No No
1Z0A_A Ras-related protein Rab-2A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 62.9 35.5 Yes No
2 bound 1.86 70.5 18.5 No No
3 empty 1.91 64.2 17.2 No No
4 empty 2.31 65.2 22.8 No No
5 empty 2.45 62.2 18.6 No No
6 empty 2.55 67.2 8.3 No No
7 empty 2.37 67.7 13.5 No No
8 empty 2.44 69.7 10.9 No No
9 empty 2.11 64.8 9.3 No No
10 empty 2.29 60.7 5.5 No No
1Z0A_D Ras-related protein Rab-2A No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 63.9 22.9 No No
2 bound 2 72.1 17.5 No No
3 empty 1.92 64.5 16.8 No No
4 empty 2.18 64 11.9 No No
5 empty 2 63.4 10.1 No No
6 empty 1.82 65.6 10.2 No No
7 empty 1.65 76.1 9.2 No No
8 empty 1.85 59.9 9.3 No No
9 empty 2.58 65 6.6 No No
10 empty 1.7 66.4 9.7 No No
1Z0A_B Ras-related protein Rab-2A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 69.3 28.8 Yes No
2 empty 2.34 61.3 30.3 No No
3 empty 1.85 65.6 16.1 No No
4 empty 2.56 65.8 11.4 No No
5 empty 2.43 68.6 11.6 No No
6 empty 2.42 74.4 7.9 No No
7 empty 2.27 58.1 12.3 No No
8 empty 2.35 60.5 10 No No
9 empty 2.28 47.9 8.7 No No
10 empty 2.62 61.4 9.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed7
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1Z0A_A (124307) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.12Å Yes No
1Z0A_B (124308) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.12Å Yes No
1Z0A_C (124309) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.12Å Yes No
1Z0A_D (124310) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.12Å No No
1Z0A_B (4164981) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
1Z0A_C (4262335) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
1Z0A_C (4164981) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
1Z0A_A (4164981) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
1Z0A_D (4217308) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes No
1Z0A_C (4217308) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes No
1Z0A_B (4262335) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
1Z0A_D (4164981) Ras-related protein Rab-2A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins (Homo Multimer) 2.12Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RAB2A is involved in 16 interactions in the network.


Druggability
Overall Druggability Percentile: 22.74
Druggability for Cancer Therapeutics: 48.62
Druggability for Other Therapeutics: 37.53
Cancer-Associated
Cancer-associated percentile : 64.64
Network Articulation Point
Is RAB2A critical for communication in the network?


Detailed Graph Legend:Help