Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB2A (P61019) - Overview - Molecular Target Synopsis

Protein


RAB2A, Ras-related protein Rab-2A
UniProt P61019

Also Known as RAB2A_HUMAN, RAB2A, RAB2

Required for protein transport from the endoplasmic reticulum to the Golgi complex. Interacts with PRKCI.

1Z0A
GDP-BOUND RAB2A GTPASE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB2A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB2A is active in the following subcellular-locations: endoplasmic reticulum membrane, endoplasmic reticulum-golgi intermediate compartment membrane, golgi apparatus membrane, melanosome.
GO terms: RAB2A is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, Golgi apparatus, Golgi membrane, lysosomal membrane, melanosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB2A has gain in 8 cell-lines, loss in 5 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, HS578T, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 940.T, DMS 53, Hs 578T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


For RAB2A there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB2A has been screened with compounds ( bioactivities). (see details)