Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB2A (P61019) - Overview - Molecular Target Synopsis


RAB2A, Ras-related protein Rab-2A
UniProt P61019

Also Known as RAB2A_HUMAN, RAB2A, RAB2

Required for protein transport from the endoplasmic reticulum to the Golgi complex. Interacts with PRKCI.

Inspect Structure
See all 3D Structures for RAB2A

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB2A is active in the following subcellular-locations: endoplasmic reticulum membrane, endoplasmic reticulum-golgi intermediate compartment membrane, golgi apparatus membrane, melanosome.
GO terms: RAB2A is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, Golgi apparatus, Golgi membrane, lysosomal membrane, melanosome, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB2A has gain in 8 cell-lines, loss in 5 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SF_539, HS578T, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 940.T, DMS 53, Hs 578T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures

For RAB2A there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB2A has been screened with compounds ( bioactivities). (see details)