Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB4B (P61018) - Overview - Molecular Target Synopsis

Protein


RAB4B, Ras-related protein Rab-4B
UniProt P61018

Also Known as RAB4B_HUMAN, RAB4B

Protein transport. Probably involved in vesicular traffic.

2O52
CRYSTAL STRUCTURE OF HUMAN RAB4B IN COMPLEX WITH GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB4B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB4B is active in the following subcellular-locations: cell membrane.
GO terms: RAB4B is active in the following subcellular-locations: endosome, insulin-responsive compartment, perinuclear region of cytoplasm, plasma membrane, recycling endosome, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB4B has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_295, SK_MEL_28, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H345, Hs 695T, DMS 53

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RAB4B there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB4B has been screened with compounds ( bioactivities). (see details)