Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAC3 (P60763) - Overview - Molecular Target Synopsis

Protein


RAC3, Ras-related C3 botulinum toxin substrate 3
UniProt P60763

Also Known as RAC3_HUMAN, RAC3

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Interacts (via C-terminal region) with CIB1; the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.

2QME
CRYSTAL STRUCTURE OF HUMAN RAC3 IN COMPLEX WITH CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 1 (PAK1)
RCSB/PDB
Inspect Structure
See all 3D Structures for RAC3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAC3 is active in the following subcellular-locations: cell membrane, cell projection, cytoplasm, cytoskeleton, endomembrane system, lamellipodium, perinuclear region.
GO terms: RAC3 is active in the following subcellular-locations: cell periphery, cell projection, cytoplasm, cytosol, endomembrane system, extracellular exosome, filamentous actin, growth cone, lamellipodium, neuron projection, neuronal cell body, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAC3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, LOXIMVI, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCT 116, ATRFLOX, DV-90

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


For RAC3 there are:
6 structures (16 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAC3 is solved in complex with the approved drug(s):

FMN/RIBOFLAVIN 5'-PHOSPHATE (5HZH_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAC3 has been screened with 1 compounds (1 bioactivities). (see details)