Molecular Target Synopsis
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Pdxp (P60487) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 11/06/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 11/06/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria11
Chains with at least one site assessed as druggable using the relaxed criteria11


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4BX3_B Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 75.7 24 Yes Yes
2 empty 2.31 59.6 26.3 No No
3 bound 2.46 62.7 35 No No
4 empty 2.53 67.3 33.7 No No
5 empty 2.28 74.2 23.3 No No
6 empty 1.83 54.2 15.9 No No
7 empty 2.29 71.9 11.8 No No
8 empty 2.22 61.6 11.2 No No
9 empty 1.91 70 9.7 No No
10 empty 1.72 60.7 15.6 No No
4BKM_B Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 68.3 53 Yes Yes
2 empty 2.63 62.8 27.7 No No
3 empty 2.5 64.7 20 No No
4 empty 1.79 64.3 19.3 No No
5 empty 1.96 70.7 8.9 No No
6 empty 2.63 68 10.6 No No
7 empty 2.16 72.7 10.9 No No
8 empty 2.35 69.9 14.6 No No
9 empty 2.54 57.2 10.9 No No
10 empty 1.25 64.2 12.9 No No
5AES_A Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.19 67.7 57.5 Yes Yes
2 empty 2.12 67.1 20.5 No No
3 empty 2.39 73.1 27.6 No No
4 empty 2 63.8 18.1 No No
5 empty 2.18 61.6 11.8 No No
6 empty 2.01 60.5 8.3 No No
7 empty 2.16 59.6 13.6 No No
8 empty 2.88 72.1 11.8 No No
9 empty 2.58 60.6 10.2 No No
10 empty 2.49 55.7 7.9 No No
4BKM_A Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 73 41 Yes Yes
2 empty 2.53 65.9 22 No No
3 empty 2.39 63.3 26.6 No No
4 empty 2.57 69 20.1 No No
5 empty 2.06 61.5 19.8 No No
6 empty 2.21 64.6 14.3 No No
7 empty 2.3 76.5 12 No No
8 empty 2.5 58.2 11.8 No No
9 empty 2.31 70 13.5 No No
10 empty 2.03 74.9 8.3 No No
4BX3_A Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.16 69.3 42.4 Yes Yes
2 empty 2.27 64.9 31.9 No No
3 empty 2.23 70.5 17.7 No No
4 empty 2.52 65.9 28.3 No No
5 empty 2.2 71.6 23.4 No No
6 empty 2.1 59.7 16.5 No No
7 empty 2.28 75.1 11 No No
8 empty 2.28 59.7 12.2 No No
9 empty 2.03 60.6 12 No No
10 empty 1.89 64.2 10.4 No No
4BKM_C Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 72.3 40.4 Yes Yes
2 empty 2.4 66.9 24.1 No No
3 empty 2.53 64 21.2 No No
4 empty 1.77 63.4 19.5 No No
5 empty 2.03 61.8 17.3 No No
6 empty 2.11 66.1 13.7 No No
7 empty 2.3 62.6 17.6 No No
8 empty 2.53 65.1 11.7 No No
9 empty 2.6 59.6 11.6 No No
10 empty 2.3 68.1 11.7 No No
4BX2_A Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 69.8 40.7 Yes Yes
2 empty 2.41 65.9 29.6 No No
3 empty 2.22 64.3 17.7 No No
4 empty 2.21 76.7 14.7 No No
5 empty 2.55 70 22.3 No No
6 empty 2.41 62.7 15.4 No No
7 empty 1.97 57.8 16.8 No No
8 empty 2.07 67.5 10.2 No No
9 empty 2.06 63.9 14.1 No No
10 empty 2.13 58.2 11.8 No No
4BX0_A Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 62.8 24.4 Yes No
2 bound 2.12 82.1 16.7 Yes Yes
3 empty 2.5 62.1 20 No No
4 empty 2.41 66.6 14.9 No No
5 empty 2.48 58 19.5 No No
6 empty 2.07 63.1 14.7 No No
7 empty 2.13 71.8 13 No No
8 empty 2.21 58 15.5 No No
9 empty 2.77 70.7 10.5 No No
10 empty 2.24 62.1 13.1 No No
4BX2_B Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 71.5 41.8 Yes Yes
2 empty 2.47 66.4 31.1 No No
3 empty 2.15 70.2 17 No No
4 empty 2.43 59.7 17.1 No No
5 empty 2.38 61.6 19 No No
6 empty 1.81 55.9 16.2 No No
7 empty 2.5 67.3 17.1 No No
8 empty 1.91 64.5 11.7 No No
9 empty 2.58 67.3 13.7 No No
10 empty 2.23 61 12 No No
5AES_B Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 66.4 60.9 Yes Yes
2 empty 2.26 75.1 19.1 No No
3 empty 2.18 63.9 20.7 No No
4 empty 2.45 64.1 26.4 No No
5 empty 2.12 65.6 25.2 No No
6 empty 2.43 68 12.6 No No
7 empty 2.12 61.6 19.6 No No
8 empty 2.24 77.1 9.2 No No
9 empty 1.9 66.8 11.5 No No
10 empty 2.48 60.9 11 No No
4BKM_D Pyridoxal phosphate phosphatase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 72 40.1 Yes Yes
2 empty 2.49 63.2 27.5 No No
3 empty 2.23 65.6 34.7 No No
4 empty 2.5 66.5 19.5 No No
5 empty 2.05 59 20.1 No No
6 empty 2.51 66.3 11.9 No No
7 empty 2.19 73 9.7 No No
8 empty 2.48 66.3 11.3 No No
9 empty 2.11 55.9 14.2 No No
10 empty 2.57 59 12.2 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score