Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Pdxp (P60487) - Overview - Molecular Target Synopsis

Protein


Pdxp, Pyridoxal phosphate phosphatase
Enzyme Classification 3.1.3.3
UniProt P60487

Also Known as PLPP_MOUSE, Pdxp, Cin, Plp, Plpp

Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (By similarity). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (By similarity) (PubMed:24338473, PubMed:24338687). Homodimer.

5AES
CRYSTAL STRUCTURE OF MURINE CHRONOPHIN (PYRIDOXAL PHOSPHATE PHOSPHATASE) IN COMPLEX WITH A PNP-DERIVED INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for Pdxp

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
292P60487-1

Sub-cellular localization


UniProt: Pdxp is active in the following subcellular-locations: cell membrane, cell projection, cytoplasm, cytoskeleton, cytosol, lamellipodium membrane, ruffle membrane.
GO terms: Pdxp is active in the following subcellular-locations: actin cytoskeleton, cell-cell junction, cleavage furrow, contractile ring, cytoplasm, cytosol, lamellipodium membrane, midbody, ruffle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Pdxp has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

RNA Interference


Pdxp was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


For Pdxp there are:
5 structures (11 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis