Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rplC (P60438) - Overview - Molecular Target Synopsis

Protein


rplC, 50S ribosomal protein L3
UniProt P60438

Also Known as RL3_ECOLI, rplC

One of two assembly initiator proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. Part of the 50S ribosomal subunit (PubMed:365579, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Forms a cluster with proteins L14 and L19.

6QUL
STRUCTURE OF A BACTERIAL 50S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE NOVEL QUINOXOLIDINONE ANTIBIOTIC CADAZOLID
RCSB/PDB
Inspect Structure
See all 3D Structures for rplC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rplC is active in the following subcellular-locations: cytosol, cytosolic large ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rplC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rplC there are:
24 structures (24 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rplC has been screened with compounds ( bioactivities). (see details)