Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rplB (P60422) - Overview - Molecular Target Synopsis

Protein


rplB, 50S ribosomal protein L2
UniProt P60422

Also Known as RL2_ECOLI, rplB

One of the primary rRNA binding proteins (PubMed:3298242). Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation (PubMed:8722025). It has been suggested to have peptidyltransferase activity; this is highly controversial., In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G. Part of the 50S ribosomal subunit (Ref.4, PubMed:7556101, PubMed:11114255, PubMed:10094780, PubMed:10756104, PubMed:12809609, PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA (PubMed:12809609). Interacts weakly with S6 in one of the 3.5 A resolved structures.

6QUL
STRUCTURE OF A BACTERIAL 50S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE NOVEL QUINOXOLIDINONE ANTIBIOTIC CADAZOLID
RCSB/PDB
Inspect Structure
See all 3D Structures for rplB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: rplB is active in the following subcellular-locations: cytosol, cytosolic large ribosomal subunit.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rplB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rplB there are:
23 structures (23 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


rplB has been screened with compounds ( bioactivities). (see details)