Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
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(P59869) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria0


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2MEN_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 62.3 12.2 No No
2 empty 2.53 61.4 13.9 No No
3 empty 1.85 59.2 10.9 No No
4 empty 2.13 67 5.4 No No
6D8S_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 65.1 16 No No
2 empty 2.46 57 11.5 No No
3 empty 2.15 60.7 7.7 No No
4 empty 2.81 64.8 9.7 No No
5 empty 2.45 60.6 6.5 No No
6D8Q_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 66.4 9.5 No No
2 empty 1.79 53.2 10.7 No No
3 empty 3.37 63.1 5.8 No No
4 empty 2.73 67.3 5.5 No No
5 empty 2.88 56 8.7 No No
6 empty 2.38 50.3 8.8 No No
7 empty 1.91 63.2 8.2 No No
8 empty 1.76 60 6.3 No No
9 empty 2.37 72.9 7.2 No No
10 empty 2.85 54.4 6.3 No No
6D8Y_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 60.7 18.2 No No
2 empty 2.16 61.2 7.3 No No
3 empty 1.99 66.3 5.7 No No
6D8U_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 58.4 11.2 No No
2 empty 2.4 58.4 13.3 No No
3 empty 2.64 53 9.3 No No
4 empty 3.37 54.3 6.3 No No
5 empty 2.51 61.8 5.5 No No
6 empty 2.5 67.7 6.4 No No
7 empty 1.83 70.3 5.4 No No
6D8T_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.62 58.1 13.6 No No
2 empty 2.34 54 11.1 No No
3 empty 2.41 60.9 6 No No
4 empty 2.21 66.2 6.1 No No
5 empty 2.68 41.8 7.3 No No
6 empty 2.69 66.4 5.3 No No
7 empty 3.28 75.2 0 No No
6D8R_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 61.4 12.2 No No
2 empty 2.8 56.2 11.3 No No
3 empty 1.65 64.6 7.7 No No
4 empty 2.37 64.1 6.4 No No
5 empty 2.37 56.4 7.9 No No
6 empty 2.33 63 6.7 No No
7 empty 2.37 47.7 6 No No
6D93_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 59.4 15.2 No No
2 empty 2.29 63.8 9.2 No No
3 empty 2.43 54.4 7.7 No No
4 empty 2.93 56.1 7.8 No No
5 empty 3.3 59.2 6.1 No No
6 empty 2.88 74.4 5.1 No No
7 empty 2.25 52.1 6.2 No No
2MEO_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 62.5 9.9 No No
2 empty 2.13 67.6 11.7 No No
3 empty 1.75 55.6 10.6 No No
4 empty 1.11 52.1 8.4 No No
5 empty 2.15 74.4 5.4 No No
6 empty 2.46 65 6.3 No No
7 empty 2.29 56.2 6.9 No No
8 empty 2.01 55.3 6.9 No No
9 empty 1.81 64.6 7.5 No No
2ME7_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 69 8.3 No No
2 empty 2.47 66.7 10.5 No No
3 empty 2.76 54.1 7.6 No No
4 empty 2.8 48.4 6.2 No No
5 empty 3.52 71.8 5.3 No No
6 empty 2.39 61.2 5.1 No No
7 empty 1.75 58.8 7.1 No No
8 empty 2.22 50 6.8 No No
9 empty 3.43 61 4.6 No No
2LU9_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 60.8 9.2 No No
2 empty 3.21 69.4 5.6 No No
3 empty 2.66 70.7 6.1 No No
4 empty 2.18 61.7 6.9 No No
6D8H_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 55.3 16 No No
2 empty 1.87 57.7 11.8 No No
3 empty 2.69 62.3 9.2 No No
4 empty 2.23 73.5 6.8 No No
5 empty 2.28 63.1 7.5 No No
6 empty 2.97 67.5 7.9 No No
7 empty 2.7 62.4 6.7 No No
2MEL_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 58.5 11.6 No No
2 empty 2.45 70 4.8 No No
3 empty 3.34 72.7 6.3 No No
4 empty 2.81 69.1 5.2 No No
2KY3_A Potassium channel toxin alpha-KTx 5.4 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 65.7 9 No No
2 empty 2.3 64.7 5.3 No No
3 empty 2.56 66.4 8 No No
4 empty 2.33 63.2 6.2 No No
5 empty 3.75 61.1 5.4 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score