Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HTR2,HTR3,HTR13,HTR9,HTR1 (P59226) - Overview - Molecular Target Synopsis

Protein


HTR2,HTR3,HTR13,HTR9,HTR1, Histone H3.2
UniProt P59226

Also Known as H32_ARATH, HTR2,HTR3,HTR13,HTR9,HTR1

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. The H3K9meK27me dimethylated N-terminal tail of histone H3 can directly interact with the chromodomains of CMT3 and/or LHP1. Interacts with ORTH2. Interacts (via N-terminus) with ATXR5 and ATXR6 (via PHD domain).

6IP4
7 RESIDUE FRAGMENT OF
HISTONE H3.2
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH NOG AND AN H3K27ME3 PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for HTR2,HTR3,HTR13,HTR9,HTR1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: HTR2,HTR3,HTR13,HTR9,HTR1 is active in the following subcellular-locations: chromosome, nucleus.
GO terms: HTR2,HTR3,HTR13,HTR9,HTR1 is active in the following subcellular-locations: chromocenter, nucleosome, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HTR2,HTR3,HTR13,HTR9,HTR1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For HTR2,HTR3,HTR13,HTR9,HTR1 there are:
18 structures (26 chains) solved
16 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis