Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB15 (P59190) - Overview - Molecular Target Synopsis

Protein


RAB15, Ras-related protein Rab-15
UniProt P59190

Also Known as RAB15_HUMAN, RAB15

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. The GTP bound form of RAB15 interacts with REP15. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB15 is active in the following subcellular-locations: cell membrane.
GO terms: RAB15 is active in the following subcellular-locations: cilium, cytoplasm, endosome, endosome membrane, extracellular exosome, perinuclear region of cytoplasm, plasma membrane, synaptic vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB15 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, NCI_H322M, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVMANA, COLO 853, CPC-N

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, MCF-7

(see details)

3D Structures


At greater than 50% identity similarity to RAB15 there are:
41 structures (86 chains) solved
33 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB15 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB15 has been screened with compounds ( bioactivities). (see details)