Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(P59071) - Overview - Molecular Target Synopsis

Protein


, Basic phospholipase A2 VRV-PL-VIIIa
Enzyme Classification 3.1.1.4
UniProt P59071

Also Known as PA2B8_DABRR

Snake venom phospholipase A2 (PLA2) that shows weak neurotoxicity and medium anticoagulant effects by binding to factor Xa (F10) and inhibiting the prothrombinase activity (IC(50) is 130 nM) (PubMed:18062812). It also damages vital organs such as lung, liver and kidney, displays edema-inducing activities when injected into the foot pads of mice and induces necrosis of muscle cells when injected into the thigh muscle. Has a low enzymatic activity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer.

3H1X
SIMULTANEOUS INHIBITION OF ANTI-COAGULATION AND INFLAMMATION: CRYSTAL STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH INDOMETHACIN AT 1.4 A RESOLUTION REVEALS THE PRESENCE OF THE NEW COMMON LIGAND BINDING SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
121P59071-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: secreted.
GO terms: is active in the following subcellular-locations: extracellular region, other organism presynaptic membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
52 structures (64 chains) solved
30 are solved in complex with at least one small molecule ligand
10 are solved with an approved drug

is solved in complex with the approved drug(s):

BHA/AMINOSALICYLIC ACID (1SXK_A),
IBP/DEXIBUPROFEN (2PWS_A),
AIN/ASPIRIN (1TGM_A),
DIF/DICLOFENAC (1SV9_A, 2B17_A),
COU/COUMARIN (2PMJ_A),
NIM/NIMESULIDE (1ZWP_A, 2OTH_A),
IMN/INDOMETHACIN (2OTH_A, 3H1X_A),
TYL/ACETAMINOPHEN (2DPZ_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


has been screened with compounds ( bioactivities). (see details)