Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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pdxA2 (P58718) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HI1_A D-threonate 4-phosphate dehydrogenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 71 32.9 Yes Yes
2 empty 2.29 69.9 25.9 No No
3 empty 1.5 65.8 30 No No
4 empty 2.22 63.6 16.2 No No
5 empty 2 57.3 21 No No
6 empty 2.11 70.5 13.9 No No
7 empty 2.6 58.2 12.4 No No
8 empty 2.19 49.1 14.4 No No
9 empty 2.33 53.7 10.7 No No
10 empty 1.88 54.2 10.5 No No
2HI1_B D-threonate 4-phosphate dehydrogenase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 67.4 41.8 Yes Yes
2 empty 1.39 65.4 34.2 No No
3 empty 2.42 62.9 24.2 No No
4 empty 1.98 72.2 13.3 No No
5 empty 2.34 58.6 14.9 No No
6 empty 2.1 62.8 17.1 No No
7 empty 2.34 72.1 11.4 No No
8 empty 2.4 67 14 No No
9 empty 2.25 59.6 10.7 No No
10 empty 2.16 63.7 11.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HI1_A (3110106) D-threonate 4-phosphate dehydrogenase Isocitrate/Isopropylmalate dehydrogenase-like, Isocitrate/Isopropylmalate dehydrogenase-like, UNMATCHED 2.3Å Yes Yes
2HI1_A (4064226) D-threonate 4-phosphate dehydrogenase Isocitrate/Isopropylmalate dehydrogenase-like, Isocitrate/Isopropylmalate dehydrogenase-like, PdxA-like 2.3Å Yes Yes
2HI1_B (4064226) D-threonate 4-phosphate dehydrogenase Isocitrate/Isopropylmalate dehydrogenase-like, Isocitrate/Isopropylmalate dehydrogenase-like, PdxA-like 2.3Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score