Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

pdxA2 (P58718) - Overview - Molecular Target Synopsis

Protein


pdxA2, D-threonate 4-phosphate dehydrogenase
Enzyme Classification 1.1.1.408
UniProt P58718

Also Known as PDXA2_SALTY, pdxA2

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP) (PubMed:27402745). Can also use 4-hydroxy-L-threonine 4-phosphate as substrate (PubMed:27294475, PubMed:27402745). Homodimer.

2HI1
THE STRUCTURE OF A PUTATIVE 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE FROM SALMONELLA TYPHIMURIUM.
RCSB/PDB
Inspect Structure
See all 3D Structures for pdxA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
327P58718-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project pdxA2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For pdxA2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis