Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB25 (P57735) - Overview - Molecular Target Synopsis

Protein


RAB25, Ras-related protein Rab-25
UniProt P57735

Also Known as RAB25_HUMAN, RAB25, CATX8

Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.

3TSO
STRUCTURE OF THE CANCER ASSOCIATED RAB25 PROTEIN IN COMPLEX WITH FIP2
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB25

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
213ENSG00000132698ENST00000361084ENSP00000354376P57735-1

Sub-cellular localization


UniProt: RAB25 is active in the following subcellular-locations: cell membrane, cell projection, cytoplasmic vesicle, pseudopodium membrane.
GO terms: RAB25 is active in the following subcellular-locations: cytoplasmic vesicle, endosome, extracellular exosome, pseudopodium, pseudopodium membrane, recycling endosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB25 has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, HT29, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1781, NCI-H2110, HCC1599

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, MCF-7

(see details)

3D Structures


For RAB25 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB25 has been screened with compounds ( bioactivities). (see details)